Regulation of circRNA biogenesis
Chen, Ling-Ling1,2; Yang, Li2,3
2015-04
发表期刊RNA BIOLOGY
ISSN1547-6286
卷号12期号:4页码:381-388
发表状态已发表
DOI10.1080/15476286.2015.1020271
摘要Unlike linear RNAs terminated with 5 caps and 3 tails, circular RNAs are characterized by covalently closed loop structures with neither 5 to 3 polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses. With the advent of specific biochemical and computational approaches, a large number of circular RNAs from back-spliced exons (circRNAs) have been identified in various cell lines and across different species. Recent studies have uncovered that back-splicing requires canonical spliceosomal machinery and can be facilitated by both complementary sequences and specific protein factors. In this review, we highlight our current understanding of the regulation of circRNA biogenesis, including both the competition between splicing and back-splicing and the previously under-appreciated alternative circularization.
关键词alternative circularization back-splicing circularization circular RNA complementary sequence splicing
收录类别SCI
语种英语
资助项目NSFC[31471241] ; NSFC[31322018] ; NSFC[91440202]
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000352654300003
出版者TAYLOR & FRANCIS INC
WOS关键词CIRCULAR RNAS ; EXON CIRCULARIZATION ; REVEALS ; INTRONS ; VIROIDS ; BIOLOGY
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2235
专题生命科学与技术学院_特聘教授组_杨力组
生命科学与技术学院_特聘教授组_陈玲玲组
通讯作者Chen, Ling-Ling
作者单位1.Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Chen, Ling-Ling,Yang, Li. Regulation of circRNA biogenesis[J]. RNA BIOLOGY,2015,12(4):381-388.
APA Chen, Ling-Ling,&Yang, Li.(2015).Regulation of circRNA biogenesis.RNA BIOLOGY,12(4),381-388.
MLA Chen, Ling-Ling,et al."Regulation of circRNA biogenesis".RNA BIOLOGY 12.4(2015):381-388.
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