Regulation of circRNA biogenesis

doi:10.1080/15476286.2015.1020271

	Regulation of circRNA biogenesis
	Chen, Ling-Ling1,2 ; Yang, Li2,3
	2015-04
发表期刊	RNA BIOLOGY
ISSN	1547-6286
卷号	12 期号:4 页码:381-388
发表状态	已发表
DOI	10.1080/15476286.2015.1020271
摘要	Unlike linear RNAs terminated with 5 caps and 3 tails, circular RNAs are characterized by covalently closed loop structures with neither 5 to 3 polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses. With the advent of specific biochemical and computational approaches, a large number of circular RNAs from back-spliced exons (circRNAs) have been identified in various cell lines and across different species. Recent studies have uncovered that back-splicing requires canonical spliceosomal machinery and can be facilitated by both complementary sequences and specific protein factors. In this review, we highlight our current understanding of the regulation of circRNA biogenesis, including both the competition between splicing and back-splicing and the previously under-appreciated alternative circularization.
关键词	alternative circularization back-splicing circularization circular RNA complementary sequence splicing
收录类别	SCI
语种	英语
资助项目	NSFC[31471241] ; NSFC[31322018] ; NSFC[91440202]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000352654300003
出版者	TAYLOR & FRANCIS INC
WOS关键词	CIRCULAR RNAS ; EXON CIRCULARIZATION ; REVEALS ; INTRONS ; VIROIDS ; BIOLOGY
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2235
专题	生命科学与技术学院_特聘教授组_杨力组生命科学与技术学院_特聘教授组_陈玲玲组
通讯作者	Chen, Ling-Ling
作者单位	1.Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Ling-Ling,Yang, Li. Regulation of circRNA biogenesis[J]. RNA BIOLOGY,2015,12(4):381-388.
APA	Chen, Ling-Ling,&Yang, Li.(2015).Regulation of circRNA biogenesis.RNA BIOLOGY,12(4),381-388.
MLA	Chen, Ling-Ling,et al."Regulation of circRNA biogenesis".RNA BIOLOGY 12.4(2015):381-388.