Regulation of circRNA biogenesis
Chen, Ling-Ling1,2; Yang, Li2,3
2015-04
Source PublicationRNA BIOLOGY
ISSN1547-6286
Volume12Issue:4Pages:381-388
Status已发表
DOI10.1080/15476286.2015.1020271
AbstractUnlike linear RNAs terminated with 5 caps and 3 tails, circular RNAs are characterized by covalently closed loop structures with neither 5 to 3 polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses. With the advent of specific biochemical and computational approaches, a large number of circular RNAs from back-spliced exons (circRNAs) have been identified in various cell lines and across different species. Recent studies have uncovered that back-splicing requires canonical spliceosomal machinery and can be facilitated by both complementary sequences and specific protein factors. In this review, we highlight our current understanding of the regulation of circRNA biogenesis, including both the competition between splicing and back-splicing and the previously under-appreciated alternative circularization.
Keywordalternative circularization back-splicing circularization circular RNA complementary sequence splicing
Indexed BySCI
Language英语
Funding ProjectNSFC[31471241] ; NSFC[31322018] ; NSFC[91440202]
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000352654300003
PublisherTAYLOR & FRANCIS INC
WOS KeywordCIRCULAR RNAS ; EXON CIRCULARIZATION ; REVEALS ; INTRONS ; VIROIDS ; BIOLOGY
Original Document TypeArticle
Citation statistics
Cited Times:850[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2235
Collection生命科学与技术学院_特聘教授组_杨力组
生命科学与技术学院_特聘教授组_陈玲玲组
Corresponding AuthorChen, Ling-Ling
Affiliation1.Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China
First Author AffilicationSchool of Life Science and Technology
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Chen, Ling-Ling,Yang, Li. Regulation of circRNA biogenesis[J]. RNA BIOLOGY,2015,12(4):381-388.
APA Chen, Ling-Ling,&Yang, Li.(2015).Regulation of circRNA biogenesis.RNA BIOLOGY,12(4),381-388.
MLA Chen, Ling-Ling,et al."Regulation of circRNA biogenesis".RNA BIOLOGY 12.4(2015):381-388.
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