Steroids Therapy in Patients With Severe COVID-19: Association With Decreasing of Pneumonia Fibrotic Tissue Volume

doi:10.3389/fmed.2022.907727

	Steroids Therapy in Patients With Severe COVID-19: Association With Decreasing of Pneumonia Fibrotic Tissue Volume
	He, Jin-wei1 ; Su, Ying 2; Qiu, Ze-song1 ; Wu, Jiang-jie1 ; Chen, Jun 3; Luo, Zhe 2; Zhang, Yuyao1,4
	2022-07-14
发表期刊	FRONTIERS IN MEDICINE (IF:3.1[JCR-2023],3.4[5-Year])
EISSN	2296-858X
卷号	9
发表状态	已发表
DOI	10.3389/fmed.2022.907727
摘要	BackgroundWe use longitudinal chest CT images to explore the effect of steroids therapy in COVID-19 pneumonia which caused pulmonary lesion progression. Materials and MethodsWe retrospectively enrolled 78 patients with severe to critical COVID-19 pneumonia, among which 25 patients (32.1%) who received steroid therapy. Patients were further divided into two groups with severe and significant-severe illness based on clinical symptoms. Serial longitudinal chest CT scans were performed for each patient. Lung tissue was segmented into the five lung lobes and mapped into the five pulmonary tissue type categories based on Hounsfield unit value. The volume changes of normal tissue and pneumonia fibrotic tissue in the entire lung and each five lung lobes were the primary outcomes. In addition, this study calculated the changing percentage of tissue volume relative to baseline value to directly demonstrate the disease progress. ResultsSteroid therapy was associated with the decrease of pneumonia fibrotic tissue (PFT) volume proportion. For example, after four CT cycles of treatment, the volume reduction percentage of PFT in the entire lung was -59.79[+/- 12.4]% for the steroid-treated patients with severe illness, and its p-value was 0.000 compared to that (-27.54[+/- 85.81]%) in non-steroid-treated ones. However, for the patient with a significant-severe illness, PFT reduction in steroid-treated patients was -41.92[+/- 52.26]%, showing a 0.275 p-value compared to -37.18[+/- 76.49]% in non-steroid-treated ones. The PFT evolution analysis in different lung lobes indicated consistent findings as well. ConclusionSteroid therapy showed a positive effect on the COVID-19 recovery, and its effect was related to the disease severity.
关键词	COVID-19 chest-CT steroids quantitative analysis pneumonia treatment
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China["62071299","61901256","91949120"]
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:000833819700001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214778
专题	信息科学与技术学院_硕士生 iHuman研究所信息科学与技术学院_博士生信息科学与技术学院_PI研究组_张玉瑶组
通讯作者	Luo, Zhe; Zhang, Yuyao
作者单位	1.ShanghaiTech Univ, Sch Informat Sci & Technol, Shanghai, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Dept Crit Care Med, Shanghai, Peoples R China 3.Wuhan Univ, Dept Radiol, Renmin Hosp, Wuhan, Peoples R China 4.ShanghaiTech Univ, IHuman Inst, Shanghai, Peoples R China
第一作者单位	信息科学与技术学院
通讯作者单位	信息科学与技术学院; iHuman研究所
第一作者的第一单位	信息科学与技术学院
推荐引用方式 GB/T 7714	He, Jin-wei,Su, Ying,Qiu, Ze-song,et al. Steroids Therapy in Patients With Severe COVID-19: Association With Decreasing of Pneumonia Fibrotic Tissue Volume[J]. FRONTIERS IN MEDICINE,2022,9.
APA	He, Jin-wei.,Su, Ying.,Qiu, Ze-song.,Wu, Jiang-jie.,Chen, Jun.,...&Zhang, Yuyao.(2022).Steroids Therapy in Patients With Severe COVID-19: Association With Decreasing of Pneumonia Fibrotic Tissue Volume.FRONTIERS IN MEDICINE,9.
MLA	He, Jin-wei,et al."Steroids Therapy in Patients With Severe COVID-19: Association With Decreasing of Pneumonia Fibrotic Tissue Volume".FRONTIERS IN MEDICINE 9(2022).