上海科技大学知识管理系统

Provided is an anti-coronavirus application of a compound. An application of a compound or a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof, or a crystal form thereof in the preparation of an anti-coronavirus preparation, wherein the compound is selected from one or more of gossypol acetate acid, mecobalamin, ertapenem, chaetomin, netilmicin sulfate, sennoside A, and ellagic acid. According to the application, the compound can effectively inhibit RNA polymerase (RDRP) on which coronavirus RNA is dependent, thereby inhibiting the proliferation of coronavirus in the anti-coronavirus application. The application has strong inhibition effects, low costs and small dosage requirements, and can be effectively used against coronavirus.

一种化合物的抗冠状病毒应用。 化合物或其药学上可接受的盐的应用， 其溶剂化物，其药学上可接受的盐的溶剂化物或其在制备抗冠状病毒制剂中的晶形，其中所述化合物选自乙酸棉酚，甲钴胺，厄他培南，木瓜素，硫酸奈替米星，番泻苷A和鞣花酸中的一种或多种。 本发明化合物能够有效抑制冠状病毒RNA依赖的RNA聚合酶(RDRP)，从而抑制冠状病毒在抗冠状病毒应用中的增殖。 本发明抑制作用强，成本低，用药量少，能有效地抗冠状病毒。