Systematic identification of rabbit LncRNAs reveals functional roles in atherosclerosis

doi:10.1016/j.bbadis.2017.12.040

	Systematic identification of rabbit LncRNAs reveals functional roles in atherosclerosis
	Li, Jia1,2,3 ; Yao, Qianlan 4; Feng, Fangyoumin1,2,3 ; He, Sheng1,2,3 ; Lin, Ping 2,3; Yang, Liguang 2,3; Yang, Chuhua 2,3; Li, Hong 2; Li, Yixue1,2,4
	2018-06
发表期刊	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (IF:4.2[JCR-2023],5.5[5-Year])
ISSN	0925-4439
卷号	1864 期号:6 页码:2266-2273
发表状态	已发表
DOI	10.1016/j.bbadis.2017.12.040
摘要	Long noncoding RNAs (lncRNAs) have been gradually emerging as important regulators in various biological processes and diseases, while the contributions of lncRNAs to atherosclerosis remain largely unknown. Our previous work has discovered atherosclerosis associated protein-coding genes by transcriptome sequencing of rabbit models. Here we investigated the roles of lncRNAs in atherosclerosis. We defined a stringent set of 3736 multi-exonic lncRNA transcripts in rabbits. All lncRNAs are firstly reported and 609 (16.3%) of them are conserved in 13 species. Rabbit IncRNAs have similar characteristics to lncRNAs in other mammals, such as relatively short length, low expression, and highly tissue-specificity. The integrative analysis of lncRNAs and co expressed genes characterize diverse functions of IncRNAs. Comparing two kinds of atherosclerosis models (LDLR-deficient WHHL rabbits and cholesterol-fed NZW rabbits) with their corresponding controls, we found the expression changes of two rabbit models were similar in aorta in but different in liver. The shared change in aorta revealed a subset of lncRNAs involved in immune response, while the cholesterol-fed NZW rabbits showed broader lncRNA expression changes in skeletal muscle system compared to WHHL rabbits. These atherosclerosis associated IncRNAs and genes provide hits for the experimental validation of IncRNA functions. In summary, our study systematically identified rabbit lncRNAs for the first time and provides new insights for understanding the functions of lncRNAs in atherosclerosis. This article is part of a Special Issue entitled: Accelerating Precision Medicine through Genetic and Genomic Big Data Analysis edited by Yudong Cai & Tao Huang.
关键词	IncRNA Rabbit Atherosclerosis
收录类别	SCI ; SCIE
语种	英语
资助项目	National High Tech RD Program (863)[2015AA020105]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000432105500007
出版者	ELSEVIER SCIENCE BV
WOS关键词	LONG NONCODING RNAS ; EXPRESSION ; TRANSCRIPTOME ; EVOLUTION ; GENOME
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/20854
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_李亦学组生命科学与技术学院_博士生
通讯作者	Li, Hong; Li, Yixue
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Comp Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200031, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Jia,Yao, Qianlan,Feng, Fangyoumin,et al. Systematic identification of rabbit LncRNAs reveals functional roles in atherosclerosis[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2018,1864(6):2266-2273.
APA	Li, Jia.,Yao, Qianlan.,Feng, Fangyoumin.,He, Sheng.,Lin, Ping.,...&Li, Yixue.(2018).Systematic identification of rabbit LncRNAs reveals functional roles in atherosclerosis.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1864(6),2266-2273.
MLA	Li, Jia,et al."Systematic identification of rabbit LncRNAs reveals functional roles in atherosclerosis".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1864.6(2018):2266-2273.