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The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex | |
2015-12 | |
发表期刊 | NATURE STRUCTURAL & MOLECULAR BIOLOGY
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ISSN | 1545-9993 |
卷号 | 22期号:12页码:1023-1026 |
发表状态 | 已发表 |
DOI | 10.1038/nsmb.3126 |
摘要 | Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | US Department of Energy, Office of Science, Office of Basic Energy Sciences[DE-AC02-06CH11357] |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
WOS记录号 | WOS:000366152400016 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | LENGTH REGULATION ; STRUCTURAL BASIS ; DNA-BINDING ; HOLOENZYME ; PROTEINS ; REPLICATION ; RPA ; PROCESSIVITY ; PROTECTION ; ACTIVATION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2078 |
专题 | 生命科学与技术学院 生命科学与技术学院_特聘教授组_雷鸣组 生命科学与技术学院_博士生 |
通讯作者 | Lei, Ming |
作者单位 | 1.Chinese Acad Sci, Natl Ctr Prot Sci Shanghai, State Key Lab Mol Biol, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Sci Res Ctr, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 4.Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA 5.Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China 6.Northwestern Univ, Ctr Synchrotron Res, Life Sci Collaborat Access Team, Argonne, IL USA |
推荐引用方式 GB/T 7714 | Wan, Bingbing,Tang, Ting,Upton, Heather,et al. The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY,2015,22(12):1023-1026. |
APA | Wan, Bingbing.,Tang, Ting.,Upton, Heather.,Shuai, Jin.,Zhou, Yuanzhe.,...&Lei, Ming.(2015).The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.NATURE STRUCTURAL & MOLECULAR BIOLOGY,22(12),1023-1026. |
MLA | Wan, Bingbing,et al."The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex".NATURE STRUCTURAL & MOLECULAR BIOLOGY 22.12(2015):1023-1026. |
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