Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells

doi:10.1039/c5tx00378d

	Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells
	Ba, Qian 1,2; Huang, Chao 1; Fu, Yijing 1; Li, Junyang 1; Li, Jingquan 1,2; Chu, Ruiai 1,2; Jia, Xudong 2; Wang, Hui1,2,3
	2016
发表期刊	TOXICOLOGY RESEARCH (IF:2.2[JCR-2023],2.6[5-Year])
ISSN	2045-452X
卷号	5 期号:1 页码:107-115
发表状态	已发表
DOI	10.1039/c5tx00378d
摘要	Benzo(a)pyrene (B[a]P) is a common environmental and foodborne pollutant which has been identified as a Group I carcinogen. Although the carcinogenicity of B[a]P has been illustrated, its comprehensive influence on metabolism and further relevance in adverse health outcomes are not well understood. To investigate the global metabolic effects of long-term B[a]P exposure at environmental dosage, we utilized the human SMMC-7721 cell-based B[a]P exposure models to perform a metabolomics study and network analysis. A total of 316 biochemicals were identified and 104 metabolites were found to be significantly altered. Bioinformatics analysis showed that the amino acid, carbohydrate, and lipid metabolism pathways and the nucleotide metabolism pathway were influenced by prolonged B[a]P exposure. Notably, the metabolic effects of B[a]P varied with different dosages. In addition, B[a]P exposure caused a decline in the glycolysis process but enhanced the glycolytic capability of SMMC-7721 cells in vitro. These findings establish the overall B[a]P-induced metabolic network, characterize the metabolic effects of chronic and environmental B[a]P exposure on human-relevant cells, and enhance the understanding of the adverse outcome pathway frame of B[a]P.
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[14391901800]
WOS研究方向	Toxicology
WOS类目	Toxicology
WOS记录号	WOS:000366832700008
出版者	ROYAL SOC CHEMISTRY
WOS关键词	POLYCYCLIC AROMATIC-HYDROCARBONS ; QUANTIFICATION ; CARCINOGENESIS ; RESPONSES ; SERUM ; TOOL
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2061
专题	生命科学与技术学院_特聘教授组_王慧组
通讯作者	Ba, Qian
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China 2.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Ba, Qian,Huang, Chao,Fu, Yijing,et al. Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells[J]. TOXICOLOGY RESEARCH,2016,5(1):107-115.
APA	Ba, Qian.,Huang, Chao.,Fu, Yijing.,Li, Junyang.,Li, Jingquan.,...&Wang, Hui.(2016).Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells.TOXICOLOGY RESEARCH,5(1),107-115.
MLA	Ba, Qian,et al."Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells".TOXICOLOGY RESEARCH 5.1(2016):107-115.