Amygdala hyper-connectivity in a mouse model of unpredictable early life stress

doi:10.1038/s41398-018-0092-z

KMS > iHuman研究所 > PI研究组 > Garth John Thompson组

	Amygdala hyper-connectivity in a mouse model of unpredictable early life stress
	Johnson, Frances K.1; Delpech, Jean-Christophe 1,2; Thompson, Garth J.3,4,5 ; Wei, Lan 1; Hao, Jin 1; Herman, Peter 3,4; Hyder, Fahmeed 3,4,6; Kaffman, Arie 1
	2018-02-21
发表期刊	TRANSLATIONAL PSYCHIATRY (IF:5.8[JCR-2023],6.3[5-Year])
ISSN	2158-3188
卷号	8
发表状态	已发表
DOI	10.1038/s41398-018-0092-z
摘要	Childhood maltreatment is associated with a wide range of psychopathologies including anxiety that emerge in childhood and in many cases persist in adulthood. Increased amygdala activation in response to threat and abnormal amygdala connectivity with frontolimbic brain regions, such as the hippocampus and the prefrontal cortex, are some of the most consistent findings seen in individuals exposed to childhood maltreatment. The underlying mechanisms responsible for these changes are difficult to study in humans but can be elucidated using animal models of early-life stress. Such studies are especially powerful in the mouse where precise control of the genetic background and the stress paradigm can be coupled with resting-state fMRI (rsfMRI) to map abnormal connectivity in circuits that regulate anxiety. To address this issue we first compared the effects of two models of early-life stress, limited bedding (LB) and unpredictable postnatal stress (UPS), on anxiety-like behavior in juvenile and adult mice. We found that UPS, but not LB, causes a robust increase in anxiety in juvenile and adult male mice. Next, we used rsfMRI to compare frontolimbic connectivity in control and UPS adult male mice. We found increased amygdala-prefrontal cortex and amygdala-hippocampus connectivity in UPS. The strength of the amygdala-hippocampal and amygdala-prefrontal cortex connectivity was highly correlated with anxiety-like behavior in the open-field test and elevated plus maze. These findings are the first to link hyperconnectivity in frontolimbic circuits and increased anxiety in a mouse model of early-life stress, allowing for more mechanistic understanding of parallel findings in humans.
收录类别	SCI ; SCIE ; SSCI
语种	英语
资助项目	NINDS[P30 NS-052519]
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000428349000001
出版者	NATURE PUBLISHING GROUP
WOS关键词	STATE FUNCTIONAL CONNECTIVITY ; CHILDHOOD ADVERSITY ; PSYCHIATRIC-DISORDERS ; MATERNAL-CARE ; SEXUAL-ABUSE ; MICE ; THREAT ; ACTIVATION ; MICROGLIA ; BEHAVIOR
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/18263
专题	iHuman研究所_PI研究组_Garth John Thompson组
通讯作者	Kaffman, Arie
作者单位	1.Yale Univ, Sch Med, Dept Psychiat, 300 George St,Suite 901, New Haven, CT 06511 USA 2.Harvard Med Sch, Boston Childrens Hosp, Dept Newborn Med, Boston, MA 02115 USA 3.Yale Univ, Dept Radiol, New Haven, CT 06520 USA 4.Yale Univ, Biomed Imaging & Magnet Resonance Res Ctr, New Haven, CT 06520 USA 5.ShanghaiTech Univ, iHuman Inst, 393 Middle Huaxia Rd,Ren Bldg,Room B204, Shanghai 201210, Peoples R China 6.Yale Univ, Dept Biomed Engn, New Haven, CT 06519 USA
推荐引用方式 GB/T 7714	Johnson, Frances K.,Delpech, Jean-Christophe,Thompson, Garth J.,et al. Amygdala hyper-connectivity in a mouse model of unpredictable early life stress[J]. TRANSLATIONAL PSYCHIATRY,2018,8.
APA	Johnson, Frances K..,Delpech, Jean-Christophe.,Thompson, Garth J..,Wei, Lan.,Hao, Jin.,...&Kaffman, Arie.(2018).Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.TRANSLATIONAL PSYCHIATRY,8.
MLA	Johnson, Frances K.,et al."Amygdala hyper-connectivity in a mouse model of unpredictable early life stress".TRANSLATIONAL PSYCHIATRY 8(2018).