Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries

doi:10.1002/anie.201603052

KMS > 免疫化学研究所 > 特聘教授组 > Richard A. Lerner组

	Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries
	Zhang, Hongkai 1; Du, Mingjuan2 ; Xie, Jia 1; Liu, Xiao2 ; Sun, Jingying2 ; Wang, Wei2 ; Xin, Xiu2 ; Possani, Lourival D.3; Yea, Kyungmoo 1; Lerner, Richard A.1
	2016-08
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year])
ISSN	1433-7851
卷号	55 期号:32 页码:9306-9310
发表状态	已发表
DOI	10.1002/anie.201603052
摘要	Animal venoms represent a rich source of pharmacologically active peptides that interact with ion channels. However, a challenge to discovering drugs remains because of the slow pace at which venom peptides are discovered and refined. An efficient autocrine-based high-throughput selection system was developed to discover and refine venom peptides that target ion channels. The utility of this system was demonstrated by the discovery of novel Kv1.3 channel blockers from a natural venom peptide library that was formatted for autocrine-based selection. We also engineered a Kv1.3 blocker peptide (ShK) derived from sea anemone to generate a subtype-selective Kv1.3 blocker with a long half-life in vivo.
关键词	drug discovery ion channels peptide drugs peptides venom peptides
收录类别	SCI ; EI
语种	英语
资助项目	JPB Foundation[]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000383371800033
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20162302453218
EI主题词	Drug products ; Ions
WOS关键词	ANTIBODY LIBRARIES ; AUTOIMMUNE-DISEASES ; FILAMENTOUS PHAGE ; TOXINS ; POTENT ; CELLS ; KV1.3 ; SHK
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1771
专题	免疫化学研究所_特聘教授组_抗体设计学实验室生命科学与技术学院免疫化学研究所_公共科研平台_信息平台生命科学与技术学院_硕士生
通讯作者	Zhang, Hongkai; Lerner, Richard A.
作者单位	1.Scripps Res Inst, Dept Mol & Cellular Biol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA 2.Shanghai Tech Univ, Inst Adv Immunochem Studies, 99 Haike Rd, Shanghai 201210, Peoples R China 3.Univ Nacl Autonoma Mexico, Inst Biotecnol, Dept Med Mol Bioproc, Apartado Postal 510-3, Cuernavaca 62250, Morelos, Mexico
推荐引用方式 GB/T 7714	Zhang, Hongkai,Du, Mingjuan,Xie, Jia,et al. Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(32):9306-9310.
APA	Zhang, Hongkai.,Du, Mingjuan.,Xie, Jia.,Liu, Xiao.,Sun, Jingying.,...&Lerner, Richard A..(2016).Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(32),9306-9310.
MLA	Zhang, Hongkai,et al."Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.32(2016):9306-9310.