Ancestral Origins and Genetic History of Tibetan Highlanders

doi:10.1016/j.ajhg.2016.07.002

	Ancestral Origins and Genetic History of Tibetan Highlanders
	Lu, Dongsheng 1,2; Lou, Haiyi 1; Yuan, Kai 1,2; Wang, Xiaoji1,2,3 ; Wang, Yuchen 1,2; Zhang, Chao 1,2; Lu, Yan 1; Yang, Xiong 1,2; Deng, Lian 1,2; Zhou, Ying 1,2; Feng, Qidi 1,2; Hu, Ya 4,5; Ding, Qiliang 4,5; Yang, Yajun 4,5; Li, Shilin 4,5; Jin, Li 4,5; Guan, Yaqun 6; Su, Bing 7; Kang, Longli 8; Xu, Shuhua1,2,3,9
	2016-09
发表期刊	AMERICAN JOURNAL OF HUMAN GENETICS (IF:8.1[JCR-2023],9.7[5-Year])
ISSN	0002-9297
卷号	99 期号:3 页码:580-594
发表状态	已发表
DOI	10.1016/j.ajhg.2016.07.002
摘要	The origin of Tibetans remains one of the most contentious puzzles in history, anthropology, and genetics. Analyses of deeply sequenced (30x-60x) genomes of 38 Tibetan highlanders and 39 Han Chinese lowlanders, together with available data on archaic and modem humans, allow us to comprehensively characterize the ancestral makeup of Tibetans and uncover their origins. Non-modem human sequences compose-6% of the Tibetan gene pool and form unique haplotypes in some genomic regions, where Denisovan-like, Neanderthal -like, ancient-Siberian-like, and unknown ancestries are entangled and elevated. The shared ancestry of Tibetan-enriched sequences dates back to similar to 62,000-38,000 years ago, predating the Last Glacial Maximum (LGM) and representing early colonization of the plateau. Nonetheless, most of the Tibetan gene pool is of modern human origin and diverged from that of Han Chinese similar to 15,000 to similar to 9,000 years ago, which can be largely attributed to post-LGM arrivals. Analysis of similar to 200 contemporary populations showed that Tibetans share ancestry with populations from East Asia (-82%), Central Asia and Siberia (similar to 11%), South Asia (similar to 6%), and western Eurasia and Oceania (similar to 1%). Our results support that Tibetans arose from a mixture of multiple ancestral gene pools but that their origins are much more complicated and ancient than previously suspected. We provide compelling evidence of the co-existence of Paleolithic and Neolithic ancestries in the Tibetan gene pool, indicating a genetic continuity between pre-historical highland-foragers and presentday Tibetans. In particular, highly differentiated sequences harbored in highlanders' genomes were most likely inherited from pre-LGM settlers of multiple ancestral origins (SUNDer) and maintained in high frequency by natural selection.
收录类别	SCI
语种	英语
资助项目	National High-Tech Research and Development Program[2012AA021802]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000383114800005
出版者	CELL PRESS
WOS关键词	GENOME SEQUENCE ; HIGH-ALTITUDE ; MUTATION-RATE ; NEANDERTHAL ; HAPLOTYPES ; INTROGRESSION ; ADAPTATION ; SETTLEMENT ; FRAMEWORK ; ADMIXTURE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1726
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_徐书华组生命科学与技术学院_硕士生
通讯作者	Xu, Shuhua
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Max Planck Independent Res, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.Fudan Univ, State Key Lab Genet Engn, Sch Life Sci, Shanghai 200433, Peoples R China 5.Fudan Univ, Minist Educ, Sch Life Sci, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China 6.Xinjiang Med Univ, Dept Biochem & Mol Biol, Preclin Med Coll, Urumqi 830011, Peoples R China 7.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China 8.Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China 9.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Lu, Dongsheng,Lou, Haiyi,Yuan, Kai,et al. Ancestral Origins and Genetic History of Tibetan Highlanders[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2016,99(3):580-594.
APA	Lu, Dongsheng.,Lou, Haiyi.,Yuan, Kai.,Wang, Xiaoji.,Wang, Yuchen.,...&Xu, Shuhua.(2016).Ancestral Origins and Genetic History of Tibetan Highlanders.AMERICAN JOURNAL OF HUMAN GENETICS,99(3),580-594.
MLA	Lu, Dongsheng,et al."Ancestral Origins and Genetic History of Tibetan Highlanders".AMERICAN JOURNAL OF HUMAN GENETICS 99.3(2016):580-594.