The Potential to Fight Obesity with Adipogenesis Modulating Compounds
Zhao, Jiaqi; Zhou, Ailin; Qi, Wei
2022-02
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
EISSN1422-0067
卷号23期号:4
发表状态已发表
DOI10.3390/ijms23042299
摘要Obesity is an increasingly severe public health problem, which brings huge social and economic burdens. Increased body adiposity in obesity is not only tightly associated with type 2 diabetes, but also significantly increases the risks of other chronic diseases including cardiovascular diseases, fatty liver diseases and cancers. Adipogenesis describes the process of the differentiation and maturation of adipocytes, which accumulate in distributed adipose tissue at various sites in the body. The major functions of white adipocytes are to store energy as fat during periods when energy intake exceeds expenditure and to mobilize this stored fuel when energy expenditure exceeds intake. Brown/beige adipocytes contribute to non-shivering thermogenesis upon cold exposure and adrenergic stimulation, and thereby promote energy consumption. The imbalance of energy intake and expenditure causes obesity. Recent interest in epigenetics and signaling pathways has utilized small molecule tools aimed at modifying obesity-specific gene expression. In this review, we discuss compounds with adipogenesis-related signaling pathways and epigenetic modulating properties that have been identified as potential therapeutic agents which cast some light on the future treatment of obesity.
关键词obesity adipogenesis AMPK BMP epigenetics sirtuin
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收录类别SCI ; SCIE
语种英语
资助项目Ministry of Science and Technology[2018YFA0800302] ; National Natural Science Foundation of China[32070609]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000771665700001
出版者MDPI
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/169222
专题生命科学与技术学院_PI研究组_戚炜组
生命科学与技术学院_博士生
生命科学与技术学院_本科生
通讯作者Qi, Wei
作者单位ShanghaiTech Univ, Sch Life Sci & Technol, Gene Editing Ctr, Shanghai 201210, Peoples R China
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
第一作者的第一单位生命科学与技术学院
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Zhao, Jiaqi,Zhou, Ailin,Qi, Wei. The Potential to Fight Obesity with Adipogenesis Modulating Compounds[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(4).
APA Zhao, Jiaqi,Zhou, Ailin,&Qi, Wei.(2022).The Potential to Fight Obesity with Adipogenesis Modulating Compounds.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(4).
MLA Zhao, Jiaqi,et al."The Potential to Fight Obesity with Adipogenesis Modulating Compounds".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.4(2022).
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