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The Potential to Fight Obesity with Adipogenesis Modulating Compounds | |
Zhao, Jiaqi; Zhou, Ailin; Qi, Wei | |
2022-02 | |
发表期刊 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
EISSN | 1422-0067 |
卷号 | 23期号:4 |
发表状态 | 已发表 |
DOI | 10.3390/ijms23042299 |
摘要 | Obesity is an increasingly severe public health problem, which brings huge social and economic burdens. Increased body adiposity in obesity is not only tightly associated with type 2 diabetes, but also significantly increases the risks of other chronic diseases including cardiovascular diseases, fatty liver diseases and cancers. Adipogenesis describes the process of the differentiation and maturation of adipocytes, which accumulate in distributed adipose tissue at various sites in the body. The major functions of white adipocytes are to store energy as fat during periods when energy intake exceeds expenditure and to mobilize this stored fuel when energy expenditure exceeds intake. Brown/beige adipocytes contribute to non-shivering thermogenesis upon cold exposure and adrenergic stimulation, and thereby promote energy consumption. The imbalance of energy intake and expenditure causes obesity. Recent interest in epigenetics and signaling pathways has utilized small molecule tools aimed at modifying obesity-specific gene expression. In this review, we discuss compounds with adipogenesis-related signaling pathways and epigenetic modulating properties that have been identified as potential therapeutic agents which cast some light on the future treatment of obesity. |
关键词 | obesity adipogenesis AMPK BMP epigenetics sirtuin |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | Ministry of Science and Technology[2018YFA0800302] ; National Natural Science Foundation of China[32070609] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
WOS记录号 | WOS:000771665700001 |
出版者 | MDPI |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/169222 |
专题 | 生命科学与技术学院_PI研究组_戚炜组 生命科学与技术学院_博士生 生命科学与技术学院_本科生 |
通讯作者 | Qi, Wei |
作者单位 | ShanghaiTech Univ, Sch Life Sci & Technol, Gene Editing Ctr, Shanghai 201210, Peoples R China |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
第一作者的第一单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Zhao, Jiaqi,Zhou, Ailin,Qi, Wei. The Potential to Fight Obesity with Adipogenesis Modulating Compounds[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(4). |
APA | Zhao, Jiaqi,Zhou, Ailin,&Qi, Wei.(2022).The Potential to Fight Obesity with Adipogenesis Modulating Compounds.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(4). |
MLA | Zhao, Jiaqi,et al."The Potential to Fight Obesity with Adipogenesis Modulating Compounds".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.4(2022). |
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