Novel Diterpenoids from the Twigs of Podocarpus nagi
Zheng, Yuan-Dong1,2,3; Guan, Xing-Chen4; Li, Dan5; Wang, An-Qi5; Ke, Chang-Qiang1,2; Tang, Chun-Ping1,2; Lin, Li-Gen5; Ye, Yang1,2,3; Wang, Zheng-Liang4; Yao, Sheng1,2
2016-10
发表期刊MOLECULES
ISSN1420-3049
卷号21期号:10
发表状态已发表
DOI10.3390/molecules21101282
摘要Phytochemical investigation of the twigs of Podocarpus nagi (Podocarpaceae) led to the isolation of two new abietane-type diterpenoids, named 1 beta,16-dihydroxylambertic acid (1) and 3 beta,16-dihydroxylambertic acid (2), along with two new ent-pimarane-type diterpenoids, named ent-2 beta,15,16,18-tetrahydroxypimar-8(14)-ene (3) and ent-15-oxo-2 beta,16,18-trihydroxypimar-8(14)-ene (4). Their respective structures were elucidated on the basis of spectroscopic analyses, including 1D-and 2D-NMR, IR, CD, and HR-ESI-MS. This is the first time ent-pimarane-type diterpenoids from the genus Podocarpus has been reported. All four new compounds were tested for cytotoxic activity. The MTT assay results showed that compounds 3 and 4 significantly inhibited the proliferation of human cervical cancer Hela cells, human lung cancer A549 cells, and human breast cancer MCF-7 cells at a concentration of 10 mu M. Furthermore, using the lipopolysaccharide (LPS)-stimulated RAW264.7 cells, compounds 2 and 4 were found to significantly inhibit nitrogen oxide (NO) production with IC50 values of 26.5 +/- 6.1 and 17.1 +/- 1.5 mu M, respectively.
关键词Podocarpus nagi abietane-type diterpenoid ent-pimarane-type diterpenoid cytotoxicity anti-inflammation
收录类别SCI
语种英语
资助项目Research Fund of University of Macau[MYRG2014-00020-ICMS-QRCM] ; Research Fund of University of Macau[MYRG2015-00153-ICMS-QRCM]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000389917900019
出版者MDPI AG
WOS关键词CONSTITUENTS ; DILACTONES
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1684
专题生命科学与技术学院
生命科学与技术学院_特聘教授组_叶阳组
生命科学与技术学院_博士生
通讯作者Wang, Zheng-Liang; Yao, Sheng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Dept Chem, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
4.Yangtze Univ, Sch Chem & Environm Engn, Jingzhou 434023, Peoples R China
5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
第一作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Zheng, Yuan-Dong,Guan, Xing-Chen,Li, Dan,et al. Novel Diterpenoids from the Twigs of Podocarpus nagi[J]. MOLECULES,2016,21(10).
APA Zheng, Yuan-Dong.,Guan, Xing-Chen.,Li, Dan.,Wang, An-Qi.,Ke, Chang-Qiang.,...&Yao, Sheng.(2016).Novel Diterpenoids from the Twigs of Podocarpus nagi.MOLECULES,21(10).
MLA Zheng, Yuan-Dong,et al."Novel Diterpenoids from the Twigs of Podocarpus nagi".MOLECULES 21.10(2016).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Zheng, Yuan-Dong]的文章
[Guan, Xing-Chen]的文章
[Li, Dan]的文章
百度学术
百度学术中相似的文章
[Zheng, Yuan-Dong]的文章
[Guan, Xing-Chen]的文章
[Li, Dan]的文章
必应学术
必应学术中相似的文章
[Zheng, Yuan-Dong]的文章
[Guan, Xing-Chen]的文章
[Li, Dan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10.3390@molecules21101282.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。