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Novel Diterpenoids from the Twigs of Podocarpus nagi | |
Zheng, Yuan-Dong1,2,3; Guan, Xing-Chen4; Li, Dan5; Wang, An-Qi5; Ke, Chang-Qiang1,2; Tang, Chun-Ping1,2; Lin, Li-Gen5; Ye, Yang1,2,3; Wang, Zheng-Liang4; Yao, Sheng1,2 | |
2016-10 | |
发表期刊 | MOLECULES |
ISSN | 1420-3049 |
卷号 | 21期号:10 |
发表状态 | 已发表 |
DOI | 10.3390/molecules21101282 |
摘要 | Phytochemical investigation of the twigs of Podocarpus nagi (Podocarpaceae) led to the isolation of two new abietane-type diterpenoids, named 1 beta,16-dihydroxylambertic acid (1) and 3 beta,16-dihydroxylambertic acid (2), along with two new ent-pimarane-type diterpenoids, named ent-2 beta,15,16,18-tetrahydroxypimar-8(14)-ene (3) and ent-15-oxo-2 beta,16,18-trihydroxypimar-8(14)-ene (4). Their respective structures were elucidated on the basis of spectroscopic analyses, including 1D-and 2D-NMR, IR, CD, and HR-ESI-MS. This is the first time ent-pimarane-type diterpenoids from the genus Podocarpus has been reported. All four new compounds were tested for cytotoxic activity. The MTT assay results showed that compounds 3 and 4 significantly inhibited the proliferation of human cervical cancer Hela cells, human lung cancer A549 cells, and human breast cancer MCF-7 cells at a concentration of 10 mu M. Furthermore, using the lipopolysaccharide (LPS)-stimulated RAW264.7 cells, compounds 2 and 4 were found to significantly inhibit nitrogen oxide (NO) production with IC50 values of 26.5 +/- 6.1 and 17.1 +/- 1.5 mu M, respectively. |
关键词 | Podocarpus nagi abietane-type diterpenoid ent-pimarane-type diterpenoid cytotoxicity anti-inflammation |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Research Fund of University of Macau[MYRG2014-00020-ICMS-QRCM] ; Research Fund of University of Macau[MYRG2015-00153-ICMS-QRCM] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
WOS记录号 | WOS:000389917900019 |
出版者 | MDPI AG |
WOS关键词 | CONSTITUENTS ; DILACTONES |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1684 |
专题 | 生命科学与技术学院 生命科学与技术学院_特聘教授组_叶阳组 生命科学与技术学院_博士生 |
通讯作者 | Wang, Zheng-Liang; Yao, Sheng |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Dept Chem, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 4.Yangtze Univ, Sch Chem & Environm Engn, Jingzhou 434023, Peoples R China 5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China |
第一作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Zheng, Yuan-Dong,Guan, Xing-Chen,Li, Dan,et al. Novel Diterpenoids from the Twigs of Podocarpus nagi[J]. MOLECULES,2016,21(10). |
APA | Zheng, Yuan-Dong.,Guan, Xing-Chen.,Li, Dan.,Wang, An-Qi.,Ke, Chang-Qiang.,...&Yao, Sheng.(2016).Novel Diterpenoids from the Twigs of Podocarpus nagi.MOLECULES,21(10). |
MLA | Zheng, Yuan-Dong,et al."Novel Diterpenoids from the Twigs of Podocarpus nagi".MOLECULES 21.10(2016). |
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