Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis

doi:10.1007/s12264-017-0147-9

	Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis
	Li, Changlin 1,2; Wang, Sashuang1,2,3 ; Chen, Yan 1,2; Zhang, Xu1,2,3
	2018-02
发表期刊	NEUROSCIENCE BULLETIN
ISSN	1673-7067
卷号	34 期号:1 页码:200-207
发表状态	已发表
DOI	10.1007/s12264-017-0147-9
摘要	Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion (DRG) neurons, and the generated inputs are transmitted via afferent fibers into the central nervous system. The gene expression profiles of DRG neurons contribute to the generation, transmission, and regulation of various somatosensory signals. Recently, the single-cell transcriptomes, cell types, and functional annotations of somatosensory neurons have been studied. In this review, we introduce our classification of DRG neurons based on single-cell RNA-sequencing and functional analyses, and discuss the technical approaches. Moreover, studies on the molecular and cellular mechanisms underlying somatic sensations are discussed.
关键词	Neuron type Single-cell technology Somatosensory mechanism Pain Gene profiles
收录类别	SCI ; SCIE
语种	英语
资助项目	Shanghai Science and Technology Committee[16JC1420500]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000424252700019
出版者	SPRINGER
WOS关键词	NOCICEPTIVE SENSORY NEURONS ; NEUROPATHIC PAIN ; TRANSCRIPTOME ANALYSIS ; RECEPTOR ; ITCH ; SEQ ; SUBTYPES ; MOUSE ; HETEROGENEITY ; TRANSMISSION
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16278
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_张旭组生命科学与技术学院_硕士生
通讯作者	Zhang, Xu
作者单位	1.Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, State Key Lab Neurosci, Ctr Excellence Brain Sci, Shanghai 200031, Peoples R China 3.ShanghaiTec Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Changlin,Wang, Sashuang,Chen, Yan,et al. Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis[J]. NEUROSCIENCE BULLETIN,2018,34(1):200-207.
APA	Li, Changlin,Wang, Sashuang,Chen, Yan,&Zhang, Xu.(2018).Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis.NEUROSCIENCE BULLETIN,34(1),200-207.
MLA	Li, Changlin,et al."Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis".NEUROSCIENCE BULLETIN 34.1(2018):200-207.