Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

doi:10.1038/s41467-018-03024-2

	Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma
	Yang, Biwei 1; Li, Meiyi 2,3; Tang, Wenqing 1; Liu, Weixin3,4 ; Zhang, Si 5; Chen, Luonan3,4 ; Xia, Jinglin 1,2
	2018-02-14
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	9
发表状态	已发表
DOI	10.1038/s41467-018-03024-2
摘要	Developing predictive biomarkers that can detect the tipping point before metastasis of hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To discover such early-warning signals or biomarkers of pulmonary metastasis in HCC, we analyse time-series gene expression data in spontaneous pulmonary metastasis mice HCCLM3-RFP model with our dynamic network biomarker (DNB) method, and identify CALML3 as a core DNB member. All experimental results of gain-of-function and loss-of-function studies show that CALML3 could indicate metastasis initiation and act as a suppressor of metastasis. We also reveal the biological role of CALML3 in metastasis initiation at a network level, including proximal regulation and cascading influences in dysfunctional pathways. Our further experiments and clinical samples show that DNB with CALML3 reduced pulmonary metastasis in liver cancer. Actually, loss of CALML3 predicts shorter overall and relapse-free survival in postoperative HCC patients, thus providing a prognostic biomarker and therapy target in HCC.
收录类别	SCI ; SCIE
语种	英语
资助项目	Shanghai Science and Technology Commission[14XD1401100]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000424989300003
出版者	NATURE PUBLISHING GROUP
WOS关键词	CLINICAL-FEATURES ; CANCER ; PROTEIN ; PROGNOSIS ; EXPRESSION ; IMPACT ; CELLS ; MODEL ; GENE ; KEGG
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16233
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_陈洛南组生命科学与技术学院_硕士生
通讯作者	Chen, Luonan; Xia, Jinglin
作者单位	1.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China 2.Fudan Univ, Fudan Univ Inst Fudan Minhang Acad Hlth Syst, Zhongshan Hosp, Minhang Hosp, 170 Xinsong Rd, Shanghai 201199, Peoples R China 3.Univ Chinese Acad Sci, Innovat Ctr Cell Signaling Network,Shanghai Inst, CAS Ctr Excellence Anim Evolut & Genet,Chinese Ac, Key Lab Syst Biol,CAS Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 5.Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Key Lab Glycoconjugate Res,Minist Publ Hlth, 130 Dongan Rd, Shanghai 200032, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yang, Biwei,Li, Meiyi,Tang, Wenqing,et al. Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma[J]. NATURE COMMUNICATIONS,2018,9.
APA	Yang, Biwei.,Li, Meiyi.,Tang, Wenqing.,Liu, Weixin.,Zhang, Si.,...&Xia, Jinglin.(2018).Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.NATURE COMMUNICATIONS,9.
MLA	Yang, Biwei,et al."Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma".NATURE COMMUNICATIONS 9(2018).