ShanghaiTech University Knowledge Management System
| Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma | |
| 2018-02-14 | |
| Source Publication | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| Volume | 9 |
| Status | 已发表 |
| DOI | 10.1038/s41467-018-03024-2 |
| Abstract | Developing predictive biomarkers that can detect the tipping point before metastasis of hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To discover such early-warning signals or biomarkers of pulmonary metastasis in HCC, we analyse time-series gene expression data in spontaneous pulmonary metastasis mice HCCLM3-RFP model with our dynamic network biomarker (DNB) method, and identify CALML3 as a core DNB member. All experimental results of gain-of-function and loss-of-function studies show that CALML3 could indicate metastasis initiation and act as a suppressor of metastasis. We also reveal the biological role of CALML3 in metastasis initiation at a network level, including proximal regulation and cascading influences in dysfunctional pathways. Our further experiments and clinical samples show that DNB with CALML3 reduced pulmonary metastasis in liver cancer. Actually, loss of CALML3 predicts shorter overall and relapse-free survival in postoperative HCC patients, thus providing a prognostic biomarker and therapy target in HCC. |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| Funding Project | Shanghai Science and Technology Commission[14XD1401100] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000424989300003 |
| Publisher | NATURE PUBLISHING GROUP |
| WOS Keyword | CLINICAL-FEATURES ; CANCER ; PROTEIN ; PROGNOSIS ; EXPRESSION ; IMPACT ; CELLS ; MODEL ; GENE ; KEGG |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16233 |
| Collection | 生命科学与技术学院 生命科学与技术学院_特聘教授组_陈洛南组 生命科学与技术学院_硕士生 |
| Corresponding Author | Chen, Luonan; Xia, Jinglin |
| Affiliation | 1.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China 2.Fudan Univ, Fudan Univ Inst Fudan Minhang Acad Hlth Syst, Zhongshan Hosp, Minhang Hosp, 170 Xinsong Rd, Shanghai 201199, Peoples R China 3.Univ Chinese Acad Sci, Innovat Ctr Cell Signaling Network,Shanghai Inst, CAS Ctr Excellence Anim Evolut & Genet,Chinese Ac, Key Lab Syst Biol,CAS Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 5.Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Key Lab Glycoconjugate Res,Minist Publ Hlth, 130 Dongan Rd, Shanghai 200032, Peoples R China |
| Corresponding Author Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Yang, Biwei,Li, Meiyi,Tang, Wenqing,et al. Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma[J]. NATURE COMMUNICATIONS,2018,9. |
| APA | Yang, Biwei.,Li, Meiyi.,Tang, Wenqing.,Liu, Weixin.,Zhang, Si.,...&Xia, Jinglin.(2018).Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.NATURE COMMUNICATIONS,9. |
| MLA | Yang, Biwei,et al."Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma".NATURE COMMUNICATIONS 9(2018). |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
Edit Comment
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.