Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma
2018-02-14
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
卷号9
发表状态已发表
DOI10.1038/s41467-018-03024-2
摘要Developing predictive biomarkers that can detect the tipping point before metastasis of hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To discover such early-warning signals or biomarkers of pulmonary metastasis in HCC, we analyse time-series gene expression data in spontaneous pulmonary metastasis mice HCCLM3-RFP model with our dynamic network biomarker (DNB) method, and identify CALML3 as a core DNB member. All experimental results of gain-of-function and loss-of-function studies show that CALML3 could indicate metastasis initiation and act as a suppressor of metastasis. We also reveal the biological role of CALML3 in metastasis initiation at a network level, including proximal regulation and cascading influences in dysfunctional pathways. Our further experiments and clinical samples show that DNB with CALML3 reduced pulmonary metastasis in liver cancer. Actually, loss of CALML3 predicts shorter overall and relapse-free survival in postoperative HCC patients, thus providing a prognostic biomarker and therapy target in HCC.
收录类别SCI ; SCIE
语种英语
资助项目Shanghai Science and Technology Commission[14XD1401100]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000424989300003
出版者NATURE PUBLISHING GROUP
WOS关键词CLINICAL-FEATURES ; CANCER ; PROTEIN ; PROGNOSIS ; EXPRESSION ; IMPACT ; CELLS ; MODEL ; GENE ; KEGG
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16233
专题生命科学与技术学院
生命科学与技术学院_特聘教授组_陈洛南组
生命科学与技术学院_硕士生
通讯作者Chen, Luonan; Xia, Jinglin
作者单位
1.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China
2.Fudan Univ, Fudan Univ Inst Fudan Minhang Acad Hlth Syst, Zhongshan Hosp, Minhang Hosp, 170 Xinsong Rd, Shanghai 201199, Peoples R China
3.Univ Chinese Acad Sci, Innovat Ctr Cell Signaling Network,Shanghai Inst, CAS Ctr Excellence Anim Evolut & Genet,Chinese Ac, Key Lab Syst Biol,CAS Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
5.Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Key Lab Glycoconjugate Res,Minist Publ Hlth, 130 Dongan Rd, Shanghai 200032, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Yang, Biwei,Li, Meiyi,Tang, Wenqing,et al. Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma[J]. NATURE COMMUNICATIONS,2018,9.
APA Yang, Biwei.,Li, Meiyi.,Tang, Wenqing.,Liu, Weixin.,Zhang, Si.,...&Xia, Jinglin.(2018).Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.NATURE COMMUNICATIONS,9.
MLA Yang, Biwei,et al."Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma".NATURE COMMUNICATIONS 9(2018).
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