Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma
2018-02-14
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume9
Status已发表
DOI10.1038/s41467-018-03024-2
AbstractDeveloping predictive biomarkers that can detect the tipping point before metastasis of hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To discover such early-warning signals or biomarkers of pulmonary metastasis in HCC, we analyse time-series gene expression data in spontaneous pulmonary metastasis mice HCCLM3-RFP model with our dynamic network biomarker (DNB) method, and identify CALML3 as a core DNB member. All experimental results of gain-of-function and loss-of-function studies show that CALML3 could indicate metastasis initiation and act as a suppressor of metastasis. We also reveal the biological role of CALML3 in metastasis initiation at a network level, including proximal regulation and cascading influences in dysfunctional pathways. Our further experiments and clinical samples show that DNB with CALML3 reduced pulmonary metastasis in liver cancer. Actually, loss of CALML3 predicts shorter overall and relapse-free survival in postoperative HCC patients, thus providing a prognostic biomarker and therapy target in HCC.
Indexed BySCI ; SCIE
Language英语
Funding ProjectShanghai Science and Technology Commission[14XD1401100]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000424989300003
PublisherNATURE PUBLISHING GROUP
WOS KeywordCLINICAL-FEATURES ; CANCER ; PROTEIN ; PROGNOSIS ; EXPRESSION ; IMPACT ; CELLS ; MODEL ; GENE ; KEGG
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16233
Collection生命科学与技术学院
生命科学与技术学院_特聘教授组_陈洛南组
生命科学与技术学院_硕士生
Corresponding AuthorChen, Luonan; Xia, Jinglin
Affiliation
1.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China
2.Fudan Univ, Fudan Univ Inst Fudan Minhang Acad Hlth Syst, Zhongshan Hosp, Minhang Hosp, 170 Xinsong Rd, Shanghai 201199, Peoples R China
3.Univ Chinese Acad Sci, Innovat Ctr Cell Signaling Network,Shanghai Inst, CAS Ctr Excellence Anim Evolut & Genet,Chinese Ac, Key Lab Syst Biol,CAS Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
5.Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Key Lab Glycoconjugate Res,Minist Publ Hlth, 130 Dongan Rd, Shanghai 200032, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Yang, Biwei,Li, Meiyi,Tang, Wenqing,et al. Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma[J]. NATURE COMMUNICATIONS,2018,9.
APA Yang, Biwei.,Li, Meiyi.,Tang, Wenqing.,Liu, Weixin.,Zhang, Si.,...&Xia, Jinglin.(2018).Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma.NATURE COMMUNICATIONS,9.
MLA Yang, Biwei,et al."Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma".NATURE COMMUNICATIONS 9(2018).
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