MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses
2022-01
发表期刊BIOENGINEERING-BASEL (IF:3.8[JCR-2023])
EISSN2306-5354
卷号9期号:1
发表状态已发表
DOI10.3390/bioengineering9010006
摘要Lipid accumulation in various microalgae has been found induced by nitrogen deprivation, and it controls many different genes expression. Yet, the underlying molecular mechanisms still remain largely unknown. MicroRNA (miRNAs) play a critical role in post-transcriptional gene regulation. In this study, miRNAs were hypothesized involved in lipid accumulation by nitrogen deprivation. A deep-sequencing platform was used to explore miRNAs-mediated responses induced by nitrogen deprivation in Chlamydomonas reinhardtii. The eukaryotic orthologous groups of proteins (KOG) function in the predicted target genes of miRNA with response to nitrogen deprivation were mainly involved in signal transduction mechanisms, including transcription, lipid transport, and metabolism. A total of 109 miRNA were predicted, including 79 known miRNA and 30 novel miRNA. A total of 29 miRNAs showed significantly differential expressions after nitrogen deprivation, and most of them were upregulated. A total of 10 miRNAs and their targeting genes might involve in lipid transport and metabolism biological process. This study first investigates nitrogen deprivation-regulated miRNAs in microalgae and broadens perspectives on miRNAs importance in microalgae lipid accumulation via nitrogen deprivation. This study provides theoretical guidance for the application of microalgae in bio-oil engineering production.
关键词microRNA Chlamydomonas reinhardtii lipid nitrogen deprivation
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收录类别SCI ; SCIE
语种英语
WOS研究方向Biotechnology & Applied Microbiology ; Engineering
WOS类目Biotechnology & Applied Microbiology ; Engineering, Biomedical
WOS记录号WOS:000758429100001
出版者MDPI
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/159558
专题生命科学与技术学院_博士生
生命科学与技术学院_特聘教授组_史吉平组
通讯作者Fan, Ruimei; Zhang, Baoguo
作者单位
1.Chinese Acad Sci, Shanghai Adv Res Inst, Lab Biorefinery, 99 Haike Rd, Shanghai 201210, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
4.Xinxiang Med Univ, Sino UK Joint Lab Brain Funct & Injury, Xinxiang 453003, Henan, Peoples R China
5.Xinxiang Med Univ, Dept Physiol & Neurobiol, Xinxiang 453003, Henan, Peoples R China
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Zhang, Jingxian,Shi, Jiping,Yuan, Chenyang,et al. MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses[J]. BIOENGINEERING-BASEL,2022,9(1).
APA Zhang, Jingxian.,Shi, Jiping.,Yuan, Chenyang.,Liu, Xiangcen.,Du, Guilin.,...&Zhang, Baoguo.(2022).MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses.BIOENGINEERING-BASEL,9(1).
MLA Zhang, Jingxian,et al."MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses".BIOENGINEERING-BASEL 9.1(2022).
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