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| MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses | |
| 2022-01 | |
| Source Publication | BIOENGINEERING-BASEL
 |
| EISSN | 2306-5354 |
| Volume | 9Issue:1 |
| Status | 已发表 |
| DOI | 10.3390/bioengineering9010006 |
| Abstract | Lipid accumulation in various microalgae has been found induced by nitrogen deprivation, and it controls many different genes expression. Yet, the underlying molecular mechanisms still remain largely unknown. MicroRNA (miRNAs) play a critical role in post-transcriptional gene regulation. In this study, miRNAs were hypothesized involved in lipid accumulation by nitrogen deprivation. A deep-sequencing platform was used to explore miRNAs-mediated responses induced by nitrogen deprivation in Chlamydomonas reinhardtii. The eukaryotic orthologous groups of proteins (KOG) function in the predicted target genes of miRNA with response to nitrogen deprivation were mainly involved in signal transduction mechanisms, including transcription, lipid transport, and metabolism. A total of 109 miRNA were predicted, including 79 known miRNA and 30 novel miRNA. A total of 29 miRNAs showed significantly differential expressions after nitrogen deprivation, and most of them were upregulated. A total of 10 miRNAs and their targeting genes might involve in lipid transport and metabolism biological process. This study first investigates nitrogen deprivation-regulated miRNAs in microalgae and broadens perspectives on miRNAs importance in microalgae lipid accumulation via nitrogen deprivation. This study provides theoretical guidance for the application of microalgae in bio-oil engineering production. |
| Keyword | microRNA Chlamydomonas reinhardtii lipid nitrogen deprivation |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| WOS Research Area | Biotechnology & Applied Microbiology ; Engineering |
| WOS Subject | Biotechnology & Applied Microbiology ; Engineering, Biomedical |
| WOS ID | WOS:000758429100001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/159558 |
| Collection | 生命科学与技术学院_博士生 生命科学与技术学院_特聘教授组_史吉平组 |
| Corresponding Author | Fan, Ruimei; Zhang, Baoguo |
| Affiliation | 1.Chinese Acad Sci, Shanghai Adv Res Inst, Lab Biorefinery, 99 Haike Rd, Shanghai 201210, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Xinxiang Med Univ, Sino UK Joint Lab Brain Funct & Injury, Xinxiang 453003, Henan, Peoples R China 5.Xinxiang Med Univ, Dept Physiol & Neurobiol, Xinxiang 453003, Henan, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Jingxian,Shi, Jiping,Yuan, Chenyang,et al. MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses[J]. BIOENGINEERING-BASEL,2022,9(1). |
| APA | Zhang, Jingxian.,Shi, Jiping.,Yuan, Chenyang.,Liu, Xiangcen.,Du, Guilin.,...&Zhang, Baoguo.(2022).MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses.BIOENGINEERING-BASEL,9(1). |
| MLA | Zhang, Jingxian,et al."MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses".BIOENGINEERING-BASEL 9.1(2022). |
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