KRAS/NF-kappa B/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

doi:10.1158/0008-5472.CAN-16-1898

	KRAS/NF-kappa B/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis
	Yuan, Peng 1,2; He, Xiao-Hong 1,2; Rong, Ye-Fei 3; Cao, Jing4 ; Li, Yong 5; Hu, Yun-Ping 6; Liu, Yingbin 6; Li, Dangsheng 7; Lou, Wenhui 3; Liu, Mo-Fang1,2
	2017-01
发表期刊	CANCER RESEARCH (IF:12.5[JCR-2023],11.6[5-Year])
ISSN	0008-5472
卷号	77 期号:1 页码:100-111
发表状态	已发表
DOI	10.1158/0008-5472.CAN-16-1898
摘要	KRAS activation occurring in more than 90% of pancreatic ductal adenocarcinomas (PDAC) drives progression and metastasis, but the underlying mechanisms involved in these processes are still poorly understood. Here, we show how KRAS acts through inflammatory NF-B-k signaling to activate the transcription factor YY1, which represses expression of the tumor suppressor gene miR-489. In PDAC cells, repression of miR-489 by KRAS signaling inhibited migration and metastasis by targeting the extracellular matrix factors ADAM9 and MMP7. miR-489 downregulation elevated levels of ADAM9 and MMP7, thereby enhancing the migration and metastasis of PDAC cells. Together, our results establish a pivotal mechanism of PDAC metastasis and suggest miR-489 as a candidate therapeutic target for their attack. (C) 2016 AACR.
收录类别	SCI
语种	英语
资助项目	Chinese Academy of Sciences[KJZD-EW-L01-2] ; Chinese Academy of Sciences[2013KIP202] ; Chinese Academy of Sciences[XDB19010202]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000393187900009
出版者	AMER ASSOC CANCER RESEARCH
WOS关键词	NF-KAPPA-B ; DUCTAL ADENOCARCINOMA ; BREAST-CANCER ; TRANSCRIPTION FACTOR ; EXPRESSION PATTERNS ; MICRORNA EXPRESSION ; SKELETAL MYOGENESIS ; CELL INVASION ; PROGRESSION ; INFLAMMATION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1575
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_刘默芳组生命科学与技术学院_硕士生
通讯作者	Lou, Wenhui; Liu, Mo-Fang
作者单位	1.Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Ctr RNA Res, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai, Peoples R China 3.Zhong Shan Hosp, Dept Pancreat Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 5.Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44106 USA 6.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg, Shanghai, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Informat Ctr Life Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Peng,He, Xiao-Hong,Rong, Ye-Fei,et al. KRAS/NF-kappa B/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis[J]. CANCER RESEARCH,2017,77(1):100-111.
APA	Yuan, Peng.,He, Xiao-Hong.,Rong, Ye-Fei.,Cao, Jing.,Li, Yong.,...&Liu, Mo-Fang.(2017).KRAS/NF-kappa B/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis.CANCER RESEARCH,77(1),100-111.
MLA	Yuan, Peng,et al."KRAS/NF-kappa B/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis".CANCER RESEARCH 77.1(2017):100-111.