Identification of a diverse synthetic abietane diterpenoid library for anticancer activity

doi:10.1016/j.bmcl.2016.12.032

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	Identification of a diverse synthetic abietane diterpenoid library for anticancer activity
	Xu, Hongtao1,2 ; Liu, Lili1 ; Fan, Xiaoting1,4 ; Zhang, Guanjun 3; Li, Yuanchao 2; Jiang, Biao1
	2017-02
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (IF:2.5[JCR-2023],2.4[5-Year])
ISSN	0960-894X
卷号	27 期号:3 页码:505-510
发表状态	已发表
DOI	10.1016/j.bmcl.2016.12.032
摘要	A diverse natural-product-like synthetic abietane diterpenoid library contains about 56 compounds were obtained, and evaluated for their potential in vitro cytotoxic or antitumor activity against A549, PC-3 and SKOV-3 tumor cell lines by SRB assay. Treatment of A549 cells with the most potent compound ketone 19 showed induction of apoptosis, as revealed by JC-1 mitochondrial membrane potential staining, TUNNEL assay, western blotting analysis and flow cytometry assay. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Abietic acid Triptophenolide Diverse Natural-product-like Anticancer
收录类别	SCI
语种	英语
资助项目	Open Foundation of the State Key Laboratory of Drug Research, China[SIMM1601KF-05]
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
WOS类目	Chemistry, Medicinal ; Chemistry, Organic
WOS记录号	WOS:000392900600025
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	BIOLOGICAL EVALUATION ; TRIPTOLIDE ANALOGS ; RING-DISTORTION ; DERIVATIVES ; DESIGN ; TRIPTONIDE ; COMPLEX
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1521
专题	免疫化学研究所生命科学与技术学院免疫化学研究所_特聘教授组_抗体化学实验室免疫化学研究所_特聘教授组_功能筛选实验室免疫化学研究所_特聘教授组_抗体设计学实验室生命科学与技术学院_硕士生
通讯作者	Jiang, Biao
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin 300457, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Xu, Hongtao,Liu, Lili,Fan, Xiaoting,et al. Identification of a diverse synthetic abietane diterpenoid library for anticancer activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(3):505-510.
APA	Xu, Hongtao,Liu, Lili,Fan, Xiaoting,Zhang, Guanjun,Li, Yuanchao,&Jiang, Biao.(2017).Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(3),505-510.
MLA	Xu, Hongtao,et al."Identification of a diverse synthetic abietane diterpenoid library for anticancer activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.3(2017):505-510.