A hypothalamic circuit that controls body temperature

doi:10.1073/pnas.1616255114

	A hypothalamic circuit that controls body temperature
	Zhao, Zheng-Dong1,2,3 ; Yang, Wen Z.1,2,3; Gao, Cuicui1,2,3 ; Fu, Xin1,2,3 ; Zhang, Wen 4,5; Zhou, Qian1,2,3 ; Chen, Wanpeng1,2,3 ; Ni, Xinyan1 ; Lin, Jun-Kai 4,5; Yang, Juan1 ; Xu, Xiao-Hong 4,5; Shen, Wei L.1
	2017-02-21
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	114 期号:8 页码:2042-2047
发表状态	已发表
DOI	10.1073/pnas.1616255114
摘要	The homeostatic control of body temperature is essential for survival in mammals and is known to be regulated in part by temperature-sensitive neurons in the hypothalamus. However, the specific neural pathways and corresponding neural populations have not been fully elucidated. To identify these pathways, we used cFos staining to identify neurons that are activated by a thermal challenge and found induced expression in subsets of neurons within the ventral part of the lateral preoptic nucleus (vLPO) and the dorsal part of the dorsomedial hypothalamus (DMD). Activation of GABAergic neurons in the vLPO using optogenetics reduced body temperature, along with a decrease in physical activity. Optogenetic inhibition of these neurons resulted in fever-level hyperthermia. These GABAergic neurons project from the vLPO to the DMD and optogenetic stimulation of the nerve terminals in the DMD also reduced body temperature and activity. Electrophysiological recording revealed that the vLPO GABAergic neurons suppressed neural activity in DMD neurons, and fiber photometry of calcium transients revealed that DMD neurons were activated by cold. Accordingly, activation of DMD neurons using designer receptors exclusively activated by designer drugs (DREADDs) or optogenetics increased body temperature with a strong increase in energy expenditure and activity. Finally, optogenetic inhibition of DMD neurons triggered hypothermia, similar to stimulation of the GABAergic neurons in the vLPO. Thus, vLPO GABAergic neurons suppressed the thermogenic effect of DMD neurons. In aggregate, our data identify vLPO. DMD neural pathways that reduce core temperature in response to a thermal challenge, and we show that outputs from the DMD can induce activity-induced thermogenesis.
关键词	thermoregulation preoptic area dorsomedial hypothalamus fiber photometry energy expenditure
收录类别	SCI
语种	英语
资助项目	National Nature Science Foundation of China[X-0402-14-002] ; National Nature Science Foundation of China[31471065]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000395099500089
出版者	NATL ACAD SCIENCES
WOS关键词	BROWN ADIPOSE-TISSUE ; DORSOMEDIAL HYPOTHALAMUS ; PREOPTIC AREA ; ENERGY-EXPENDITURE ; ANESTHETIZED RATS ; NEURONS ; THERMOGENESIS ; LEPTIN ; ACTIVATION ; RECEPTORS
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1504
专题	生命科学与技术学院生命科学与技术学院_PI研究组_沈伟组生命科学与技术学院_博士生
通讯作者	Shen, Wei L.
作者单位	1.ShanghaiTech Univ Shanghai, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhao, Zheng-Dong,Yang, Wen Z.,Gao, Cuicui,et al. A hypothalamic circuit that controls body temperature[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2017,114(8):2042-2047.
APA	Zhao, Zheng-Dong.,Yang, Wen Z..,Gao, Cuicui.,Fu, Xin.,Zhang, Wen.,...&Shen, Wei L..(2017).A hypothalamic circuit that controls body temperature.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,114(8),2042-2047.
MLA	Zhao, Zheng-Dong,et al."A hypothalamic circuit that controls body temperature".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114.8(2017):2042-2047.