Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles

doi:10.1016/j.artmed.2017.05.008

	Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles
	Li, Xiangyi 1,2; Xu, Yingjie 3; Cui, Hui2,5 ; Huang, Tao 4; Wang, Disong 2; Lian, Baofeng 2; Li, Wei 2; Qin, Guangrong 2; Chen, Lanming 1; Xie, Lu 2
	2017-11
发表期刊	ARTIFICIAL INTELLIGENCE IN MEDICINE
ISSN	0933-3657
卷号	83 页码:35-43
发表状态	已发表
DOI	10.1016/j.artmed.2017.05.008
摘要	Objective: Synergistic drug combinations are promising therapies for cancer treatment. However, effective prediction of synergistic drug combinations is quite challenging as mechanisms of drug synergism are still unclear. Various features such as drug response, and target networks may contribute to prediction of synergistic drug combinations. In this study, we aimed to construct a computational model to predict synergistic drug combinations.
关键词	Synergistic drug combinations Cancer Network features Gene expression profiles Random forest
收录类别	SCI ; EI
语种	英语
资助项目	Shanghai Municipal Committee of Science and Technology[14DZ1103401]
WOS研究方向	Computer Science ; Engineering ; Medical Informatics
WOS类目	Computer Science, Artificial Intelligence ; Engineering, Biomedical ; Medical Informatics
WOS记录号	WOS:000418314700004
出版者	ELSEVIER
EI入藏号	20172303733194
EI主题词	Computation theory ; Computational methods ; Decision trees ; Diseases ; Drug interactions ; Forecasting ; Genes ; Proteins ; Statistical tests
WOS关键词	PHASE-I ; RESISTANCE ; IDENTIFICATION ; TRANSPORTERS ; SIGNATURES
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/14255
专题	生命科学与技术学院生命科学与技术学院_博士生
通讯作者	Qin, Guangrong; Chen, Lanming; Xie, Lu
作者单位	1.Shanghai Ocean Univ, Key Lab Qual & Safety Risk Assessment Aquat Prod, China Minist Agr, Coll Food Sci & Technol, 999 Hu Cheng Huan Rd, Shanghai 201306, Peoples R China 2.Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol, 1278 Keyuan Rd, Shanghai 201203, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, 1111 Xianxia Rd, Shanghai 200336, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiangyi,Xu, Yingjie,Cui, Hui,et al. Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles[J]. ARTIFICIAL INTELLIGENCE IN MEDICINE,2017,83:35-43.
APA	Li, Xiangyi.,Xu, Yingjie.,Cui, Hui.,Huang, Tao.,Wang, Disong.,...&Xie, Lu.(2017).Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles.ARTIFICIAL INTELLIGENCE IN MEDICINE,83,35-43.
MLA	Li, Xiangyi,et al."Prediction of synergistic anti-cancer drug combinations based on drug target network and drug induced gene expression profiles".ARTIFICIAL INTELLIGENCE IN MEDICINE 83(2017):35-43.