Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis

doi:10.1073/pnas.2115667118

	Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis
	Cheng, Ying-Juan 1; Shang, Guan-Dong 1,2; Xu, Zhou-Geng 1,2; Yu, Sha 1; Wu, Lian-Yu1,3 ; Zhai, Dong 1,2; Tian, Shi-Long 1,2; Gao, Jian 1; Wang, Long 1; Wang, Jia-Wei1,3
	2021-11-16
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (IF:9.4[JCR-2023],10.8[5-Year])
ISSN	0027-8424
EISSN	1091-6490
卷号	118 期号:46
DOI	10.1073/pnas.2115667118
摘要	What determines the rate at which a multicellular organism matures is a fundamental question in biology. In plants, the decline of miR156 with age serves as an intrinsic, evolutionarily conserved timer for the juvenile-to-adult phase transition. However, the way in which age regulates miR156 abundance is poorly understood. Here, we show that the rate of decline in miR156 is correlated with developmental age rather than chronological age. Mechanistically, we found that cell division in the apical meristem is a trigger for miR156 decline. The transcriptional activity of MIR156 genes is gradually attenuated by the deposition of the repressive histone mark H3K27me3 along with cell division. Our findings thus provide a plausible explanation of why the maturation program of a multicellular organism is unidirectional and irreversible under normal growth conditions and suggest that cell quiescence is the fountain of youth in plants.
关键词	miR156 age developmental timing cell division
收录类别	SCIE
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000723038100022
出版者	NATL ACAD SCIENCES
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/134167
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_王佳伟组
通讯作者	Wang, Jia-Wei
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci CEMPS, Inst Plant Physiol & Ecol SIPPE, Natl Key Lab Plant Mol Genet, Shanghai 200032, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai 200032, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Cheng, Ying-Juan,Shang, Guan-Dong,Xu, Zhou-Geng,et al. Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118(46).
APA	Cheng, Ying-Juan.,Shang, Guan-Dong.,Xu, Zhou-Geng.,Yu, Sha.,Wu, Lian-Yu.,...&Wang, Jia-Wei.(2021).Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118(46).
MLA	Cheng, Ying-Juan,et al."Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118.46(2021).