ShanghaiTech University Knowledge Management System
| Click Chemistry in Natural Product Modification | |
| 2021-11-17 | |
| Source Publication | FRONTIERS IN CHEMISTRY
 |
| ISSN | 2296-2646 |
| Volume | 9 |
| DOI | 10.3389/fchem.2021.774977 |
| Abstract | Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry. |
| Keyword | natural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange pharmacological activity |
| URL | 查看原文 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000725740700001 |
| Publisher | FRONTIERS MEDIA SA |
| Original Document Type | Review |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/134146 |
| Collection | 生命科学与技术学院_博士生 免疫化学研究所_特聘教授组_抗体设计学实验室 |
| Corresponding Author | Zhao, Songfeng; Liu, Bo; Xu, Hongtao |
| Affiliation | 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou, Peoples R China; 2.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China; 3.Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Clin Med Coll 2, Guangzhou, Peoples R China |
| Corresponding Author Affilication | Shanghai Institute for Advanced Immunochemical Studies |
| Recommended Citation GB/T 7714 | Zhang, Xiang,Zhang, Shuning,Zhao, Songfeng,et al. Click Chemistry in Natural Product Modification[J]. FRONTIERS IN CHEMISTRY,2021,9. |
| APA | Zhang, Xiang,Zhang, Shuning,Zhao, Songfeng,Wang, Xuan,Liu, Bo,&Xu, Hongtao.(2021).Click Chemistry in Natural Product Modification.FRONTIERS IN CHEMISTRY,9. |
| MLA | Zhang, Xiang,et al."Click Chemistry in Natural Product Modification".FRONTIERS IN CHEMISTRY 9(2021). |
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