Click Chemistry in Natural Product Modification
2021-11-17
Source PublicationFRONTIERS IN CHEMISTRY
ISSN2296-2646
Volume9
DOI10.3389/fchem.2021.774977
AbstractClick chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry.
Keywordnatural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange pharmacological activity
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Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000725740700001
PublisherFRONTIERS MEDIA SA
Original Document TypeReview
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/134146
Collection生命科学与技术学院_博士生
免疫化学研究所_特聘教授组_抗体设计学实验室
Corresponding AuthorZhao, Songfeng; Liu, Bo; Xu, Hongtao
Affiliation
1.Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou, Peoples R China;
2.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China;
3.Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Clin Med Coll 2, Guangzhou, Peoples R China
Corresponding Author AffilicationShanghai Institute for Advanced Immunochemical Studies
Recommended Citation
GB/T 7714
Zhang, Xiang,Zhang, Shuning,Zhao, Songfeng,et al. Click Chemistry in Natural Product Modification[J]. FRONTIERS IN CHEMISTRY,2021,9.
APA Zhang, Xiang,Zhang, Shuning,Zhao, Songfeng,Wang, Xuan,Liu, Bo,&Xu, Hongtao.(2021).Click Chemistry in Natural Product Modification.FRONTIERS IN CHEMISTRY,9.
MLA Zhang, Xiang,et al."Click Chemistry in Natural Product Modification".FRONTIERS IN CHEMISTRY 9(2021).
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