Click Chemistry in Natural Product Modification

doi:10.3389/fchem.2021.774977

	Click Chemistry in Natural Product Modification
	Zhang, Xiang 1; Zhang, Shuning2 ; Zhao, Songfeng 1; Wang, Xuan 3; Liu, Bo 3; Xu, Hongtao2
	2021-11-17
发表期刊	FRONTIERS IN CHEMISTRY (IF:3.8[JCR-2023],4.8[5-Year])
ISSN	2296-2646
卷号	9
DOI	10.3389/fchem.2021.774977
摘要	Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry.
关键词	natural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange pharmacological activity
URL	查看原文
收录类别	SCIE
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000725740700001
出版者	FRONTIERS MEDIA SA
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/134146
专题	生命科学与技术学院_博士生免疫化学研究所_特聘教授组_抗体设计学实验室
通讯作者	Zhao, Songfeng; Liu, Bo; Xu, Hongtao
作者单位	1.Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou, Peoples R China; 2.Shanghai Tech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China; 3.Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Clin Med Coll 2, Guangzhou, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Zhang, Xiang,Zhang, Shuning,Zhao, Songfeng,et al. Click Chemistry in Natural Product Modification[J]. FRONTIERS IN CHEMISTRY,2021,9.
APA	Zhang, Xiang,Zhang, Shuning,Zhao, Songfeng,Wang, Xuan,Liu, Bo,&Xu, Hongtao.(2021).Click Chemistry in Natural Product Modification.FRONTIERS IN CHEMISTRY,9.
MLA	Zhang, Xiang,et al."Click Chemistry in Natural Product Modification".FRONTIERS IN CHEMISTRY 9(2021).