Cancer metabolism and tumor microenvironment: fostering each other?

doi:10.1007/s11427-021-1999-2

	Cancer metabolism and tumor microenvironment: fostering each other?
	Yuan, Yiyuan 1; Li, Huimin 2; Pu, Wang 3,4; Chen, Leilei 3,4; Guo, Dong 5,6; Jiang, Hongfei 5,6; He, Bo 7,8,9,10; Qin, Siyuan 7,8,9,10; Wang, Kui 7,8,9,10; Li, Na 11; Feng, Jingwei 12; Wen, Jing2,13 ; Cheng, Shipeng 2,13; Zhang, Yaguang 2,13; Yang, Weiwei 2; Ye, Dan 3,4; Lu, Zhimin 5,6; Huang, Canhua 7,8,9,10; Mei, Jun 11; Zhang, Hua-Feng 14; Gao, Ping 15; Jiang, Peng 16,17; Su, Shicheng 12; Sun, Bing2,13 ; Zhao, Shi-Min 1
	2021
发表期刊	SCIENCE CHINA-LIFE SCIENCES (IF:8.0[JCR-2023],7.3[5-Year])
ISSN	1674-7305
EISSN	1869-1889
DOI	10.1007/s11427-021-1999-2
摘要	The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live. Metabolic reprogramming supports tumor cell high demand of biogenesis for their rapid proliferation, and helps tumor cell to survive under certain genetic or environmental stresses. Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes, in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways. Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation. This cancer metabolic phenotype, described firstly by German physiologist Otto Warburg, insures enhanced glycolytic metabolism for the biosynthesis of macromolecules. The conception of metabolite signaling, i.e., metabolites are regulators of cell signaling, provides novel insights into how reactive oxygen species (ROS) and other metabolites deregulation may regulate redox homeostasis, epigenetics, and proliferation of cancer cells. Moreover, the unveiling of noncanonical functions of metabolic enzymes, such as the moonlighting functions of phosphoglycerate kinase 1 (PGK1), reassures the importance of metabolism in cancer development. The metabolic, microRNAs, and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome. Among them, cancer microenvironmental cells are immune cells which exert profound effects on cancer cells. Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers.
关键词	cancer metabolism cancer microenvironment epigenetics cancer immunology
收录类别	SCIE
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000723969100002
出版者	SCIENCE PRESS
原始文献类型	Review; Early Access
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/134145
专题	生命科学与技术学院_特聘教授组_孙兵组生命科学与技术学院_博士生
通讯作者	Yang, Weiwei; Ye, Dan; Lu, Zhimin; Huang, Canhua; Mei, Jun; Zhang, Hua-Feng; Gao, Ping; Jiang, Peng; Su, Shicheng; Sun, Bing; Zhao, Shi-Min
作者单位	1.Fudan Univ, State Key Lab Genet Engn, Obstet & Gynecol Hosp, Shanghai 200438, Peoples R China; 2.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 3.Fudan Univ, Mol & Cell Biol Lab, Inst Biomed Sci, Shanghai 200032, Peoples R China; 4.Fudan Univ, Sch Life Sci, Shanghai 200032, Peoples R China; 5.Zhejiang Univ, Sch Med, Zhejiang Prov Key Lab Pancreat Dis, Affiliated Hosp 1, Hangzhou 310029, Peoples R China; 6.Zhejiang Univ, Sch Med, Inst Translat Med, Hangzhou 310029, Peoples R China; 7.Sichuan Univ, West China Sch Bas Med Sci & Forens Med, Chengdu 610041, Peoples R China; 8.West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China; 9.West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China; 10.Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China; 11.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Tumor Microenvironm & Inflammat, Dept Biochem & Mol Cell Biol, Shanghai 200025, Peoples R China; 12.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China; 13.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 14.Univ Sci & Technol China, CAS Ctr Excellence Cell & Mol Biol, CAS Key Lab Innate Immun & Chron Dis, Sch Basic Med Sci,Div Life Sci & Med, Hefei 230027, Peoples R China; 15.South China Univ Technol, Sch Med, Inst Life Sci, Guangzhou 510006, Peoples R China; 16.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China; 17.Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yuan, Yiyuan,Li, Huimin,Pu, Wang,et al. Cancer metabolism and tumor microenvironment: fostering each other?[J]. SCIENCE CHINA-LIFE SCIENCES,2021.
APA	Yuan, Yiyuan.,Li, Huimin.,Pu, Wang.,Chen, Leilei.,Guo, Dong.,...&Zhao, Shi-Min.(2021).Cancer metabolism and tumor microenvironment: fostering each other?.SCIENCE CHINA-LIFE SCIENCES.
MLA	Yuan, Yiyuan,et al."Cancer metabolism and tumor microenvironment: fostering each other?".SCIENCE CHINA-LIFE SCIENCES (2021).