Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age

doi:10.1038/s41598-017-02992-7

	Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age
	Wu, Leilei 1; Pang, Shichao 4; Yao, Qianlan 1; Jian, Chen 5; Lin, Ping 2; Feng, Fangyoumin2,6 ; Li, Hong 2; Li, Yixue1,2,3
	2017-06-14
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7
发表状态	已发表
DOI	10.1038/s41598-017-02992-7
摘要	Recent cancer researches pay more attention to younger patients due to the variable treatment response among different age groups. Here we investigated the effectiveness of neoadjuvant radiation on the survival of younger and older patients in stage II/III rectal cancer. Data was obtained from Surveillance, Epidemiology, and End Results (SEER) database (n = 12801). Propensity score matching was used to balance baseline covariates according to the status of neoadjuvant radiation. Our results showed that neoadjuvant radiation had better survival benefit (Log-rank P = 3.25e-06) and improved cancer-specific 3-year (87.6%; 95% CI: 86.4-88.7% vs. 84.1%; 95% CI: 82.8-85.3%) and 5-year survival rates (78.1%; 95% CI: 76.2-80.1% vs. 77%; 95% CI: 75.3-78.8%). In older groups (> 50), neoadjuvant radiation was associated with survival benefits in stage II (HR: 0.741; 95% CI: 0.599-0.916; P = 5.80e-3) and stage III (HR: 0.656; 95% CI 0.564-0.764; P = 5.26e-08). Interestingly, neoadjuvant radiation did not increase survival rate in younger patients (< = 50) both in stage II (HR: 2.014; 95% CI: 0.9032-4.490; P = 0.087) and stage III (HR: 1.168; 95% CI: 0.829-1.646; P = 0.372). Additionally, neoadjuvant radiation significantly decreased the cancer-specific mortality in older patients, but increased mortality in younger patients. Our results provided new insights on the neoadjuvant radiation in rectal cancer, especially for the younger patients.
收录类别	SCI
语种	英语
资助项目	National Grand Program on Key Infectious Diseases[2015ZX10004801-005]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000403318400025
出版者	NATURE PUBLISHING GROUP
WOS关键词	TOTAL MESORECTAL EXCISION ; PROPENSITY SCORE METHODS ; COLORECTAL-CANCER ; PREOPERATIVE RADIOTHERAPY ; POSTOPERATIVE CHEMORADIOTHERAPY ; MICROSATELLITE INSTABILITY ; LOCAL RECURRENCE ; ADJUVANT CHEMOTHERAPY ; RANDOMIZED-TRIAL ; YOUNG-PATIENTS
原始文献类型	Article
通讯作者	Li, Hong ; Li, Yixue
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1330
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_李亦学组生命科学与技术学院_博士生
通讯作者	Li, Hong; Li, Yixue
作者单位	1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China 3.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Math Sci, Dept Stat, Shanghai 200240, Peoples R China 5.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Gen Surg, Sch Med, Shanghai 201600, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Wu, Leilei,Pang, Shichao,Yao, Qianlan,et al. Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age[J]. SCIENTIFIC REPORTS,2017,7.
APA	Wu, Leilei.,Pang, Shichao.,Yao, Qianlan.,Jian, Chen.,Lin, Ping.,...&Li, Yixue.(2017).Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age.SCIENTIFIC REPORTS,7.
MLA	Wu, Leilei,et al."Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age".SCIENTIFIC REPORTS 7(2017).