PET Imaging of Neuroinflammation in Alzheimer's Disease

doi:10.3389/fimmu.2021.739130

	PET Imaging of Neuroinflammation in Alzheimer's Disease
	Zhou, Rong 1; Ji, Bin 2; Kong, Yanyan 3; Qin, Limei 4; Ren, Wuwei5 ; Guan, Yihui 3; Ni, Ruiqing 6,7,8
	2021-09-16
发表期刊	FRONTIERS IN IMMUNOLOGY
ISSN	1664-3224
卷号	12
DOI	10.3389/fimmu.2021.739130
摘要	Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in molecular imaging using positron emission tomography have provided insights into the time course of neuroinflammation and its relation with Alzheimer's disease central pathologies in patients and in animal disease models. Recent single-cell sequencing and transcriptomics indicate dynamic disease-associated microglia and astrocyte profiles in Alzheimer's disease. Mitochondrial 18-kDa translocator protein is the most widely investigated target for neuroinflammation imaging. New generation of translocator protein tracers with improved performance have been developed and evaluated along with tau and amyloid imaging for assessing the disease progression in Alzheimer's disease continuum. Given that translocator protein is not exclusively expressed in glia, alternative targets are under rapid development, such as monoamine oxidase B, matrix metalloproteinases, colony-stimulating factor 1 receptor, imidazoline-2 binding sites, cyclooxygenase, cannabinoid-2 receptor, purinergic P2X7 receptor, P2Y12 receptor, the fractalkine receptor, triggering receptor expressed on myeloid cells 2, and receptor for advanced glycation end products. Promising targets should demonstrate a higher specificity for cellular locations with exclusive expression in microglia or astrocyte and activation status (pro- or anti-inflammatory) with highly specific ligand to enable in vivo brain imaging. In this review, we summarised recent advances in the development of neuroinflammation imaging tracers and provided an outlook for promising targets in the future.
关键词	Alzheimer's disease neuroinflammation tau microglia astrocyte amyloid (A) 42 positron emission tomography (PET) TSPO (18 kDa translocator protein)
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收录类别	SCIE
语种	英语
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000702032000001
出版者	FRONTIERS MEDIA SA
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128332
专题	信息科学与技术学院_PI研究组_任无畏组
通讯作者	Guan, Yihui; Ni, Ruiqing
作者单位	1.Tongji Univ, Yangpu Hosp, Sch Med, Dept Nephrol, Shanghai, Peoples R China; 2.Fudan Univ, Sch Pharm, Dept Radiopharm & Mol Imaging, Shanghai, Peoples R China; 3.Fudan Univ, Huashan Hosp, Positron Emiss Tomog PET Ctr, Shanghai, Peoples R China; 4.Inner Mongolia Baicaotang Qin Chinese Mongolia Ho, Hohhot, Peoples R China; 5.Shanghaitech Univ, Sch Informat Sci & Technol, Shanghai, Peoples R China; 6.Univ Zurich, Inst Regenerat Med, Zurich, Switzerland; 7.Univ Zurich, Inst Biomed Engn, Zurich, Switzerland; 8.Swiss Fed Inst Technol, Zurich, Switzerland
推荐引用方式 GB/T 7714	Zhou, Rong,Ji, Bin,Kong, Yanyan,et al. PET Imaging of Neuroinflammation in Alzheimer's Disease[J]. FRONTIERS IN IMMUNOLOGY,2021,12.
APA	Zhou, Rong.,Ji, Bin.,Kong, Yanyan.,Qin, Limei.,Ren, Wuwei.,...&Ni, Ruiqing.(2021).PET Imaging of Neuroinflammation in Alzheimer's Disease.FRONTIERS IN IMMUNOLOGY,12.
MLA	Zhou, Rong,et al."PET Imaging of Neuroinflammation in Alzheimer's Disease".FRONTIERS IN IMMUNOLOGY 12(2021).