Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans

doi:10.1002/biof.1788

	Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans
	Liu, Yalei 1; Zhou, Zhenyu 1; Yin, Liufang 1; Zhu, Mengnan2 ; Wang, Fei 1; Zhang, Lijun 1; Wang, Hongqing 1; Zhou, Zhiqin 3; Zhu, Huanhu2 ; Huang, Cheng 1; Fan, Shengjie 1
	2022-03
发表期刊	BIOFACTORS (IF:5.0[JCR-2023],5.8[5-Year])
ISSN	0951-6433
EISSN	1872-8081
DOI	10.1002/biof.1788
摘要	Tangeretin is a polymethoxylated flavonoid naturally occurred in citrus fruits with many pharmacological activities, such as anti-inflammatory, antiproliferative, and neuroprotective properties. A previous study reported that tangeretin-enriched orange extract could prolong the lifespan in Caenorhabditis elegans. However, the antiaging effect of tangeretin remains uncertain. In this study, we used the model organism C. elegans to conduct a lifespan test, observed the aging-related functional changes of nematodes, the fluorescence changes of stress-related proteins (DAF-16 and HSP-16.2) and its response to stress assay, and monitored the effect of tangeretin on the mRNA expression levels. The results showed that tangeretin supplementation (30 and 100 mu M) extended the mean lifespan, slowed aging-related functional declines, and increased the resistance against heat-shock stress. Furthermore, tangeretin upregulated the mRNA expression of daf-16, hsp-16.2, and hsp-16.49, promoted the nuclear localization of DAF-16, and enhanced the fluorescence intensity of HSP-16.2, while it had no effect on the lifespan of daf-2, age-1, and daf-16 mutants. The current findings suggest that tangeretin can significantly extend the lifespan and enhance heat stress tolerance in an insulin/insulin-like growth factor signaling dependent manner.
关键词	Caenorhabditis elegans heat resistance insulin insulin-like growth factor signaling lifespan tangeretin
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号	WOS:000700506000001
出版者	WILEY
原始文献类型	Article; Early Access
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128317
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_朱焕乎组
通讯作者	Zhu, Huanhu; Huang, Cheng; Fan, Shengjie
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 20121, Peoples R China; 3.Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Liu, Yalei,Zhou, Zhenyu,Yin, Liufang,et al. Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans[J]. BIOFACTORS,2022.
APA	Liu, Yalei.,Zhou, Zhenyu.,Yin, Liufang.,Zhu, Mengnan.,Wang, Fei.,...&Fan, Shengjie.(2022).Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans.BIOFACTORS.
MLA	Liu, Yalei,et al."Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans".BIOFACTORS (2022).