Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses

doi:10.1016/j.coi.2021.07.012

	Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses
	Luan, Haoming; Horng, Tiffany
	2021-12
发表期刊	CURRENT OPINION IN IMMUNOLOGY (IF:6.6[JCR-2023],6.5[5-Year])
ISSN	0952-7915
EISSN	1879-0372
卷号	73
DOI	10.1016/j.coi.2021.07.012
摘要	During microbial infection, macrophages link recognition of microbial stimuli to the induction of Type I inflammatory responses. Such inflammatory responses coordinate host defense and pathogen elimination but induce significant tissue damage if sustained, so macrophages are initially activated to induce inflammatory responses but then shift to a tolerant state to suppress inflammatory responses. Macrophage tolerance is regulated by induction of negative regulators of TLR signaling, but its metabolic basis was not known. Here, we review recent studies that indicate that macrophage metabolism changes dynamically over the course of microbial exposure to influence a shift in the inflammatory response. In particular, an initial increase in oxidative metabolism boosts the induction of inflammatory responses, but is followed by a shutdown of oxidative metabolism that contributes to suppression of inflammatory responses. We propose a unifying model for how dynamic changes to oxidative metabolism influences regulation of macrophage inflammatory responses during microbial exposure.
收录类别	SCIE
语种	英语
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000696570600001
出版者	CURRENT BIOLOGY LTD
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128215
专题	生命科学与技术学院_PI研究组_洪诗雅组生命科学与技术学院_博士生
通讯作者	Horng, Tiffany
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Luan, Haoming,Horng, Tiffany. Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses[J]. CURRENT OPINION IN IMMUNOLOGY,2021,73.
APA	Luan, Haoming,&Horng, Tiffany.(2021).Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses.CURRENT OPINION IN IMMUNOLOGY,73.
MLA	Luan, Haoming,et al."Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses".CURRENT OPINION IN IMMUNOLOGY 73(2021).