Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans

doi:10.1016/j.jhazmat.2021.126723

	Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans
	Ma, Xueqi1,3,4 ; Hou, Min 2; Liu, Chaobao 1; Li, Jingquan 2; Ba, Qian 2; Wang, Hui 1,2
	2022-01-05
发表期刊	JOURNAL OF HAZARDOUS MATERIALS (IF:12.2[JCR-2023],11.9[5-Year])
ISSN	0304-3894
EISSN	1873-3336
卷号	421
DOI	10.1016/j.jhazmat.2021.126723
摘要	Environmental cadmium, with a high dietary intake and long biological half-life, is a severe health risk by harming physiological function directly or through gut microbiota. However, the toxicity mechanisms of environmental cadmium on microbes and host systems remain unclear. Herein, we established three C. elegans and E. coli cultivated systems to investigate the vital role of microorganisms in cadmium-induced lipid toxicity and depict the interaction between environmental cadmium, bacteria, and the host. We found that only nematodes in the system with live bacteria, rather than UV-killed bacteria or no bacteria, could be induced to fat accumulation by cadmium exposure, suggesting that bacteria mediated the effect of environmental cadmium on body fat. Cadmium caused perturbation of metabolite in bacteria, most notably oleic acid, elevated the synthesis genes expression, and enhanced the bacterial oleic acid production, which further promoted the expression of lipid metabolism-related genes and fat deposition in C. elegans regardless of the cultivated system. Finally, we showed the potential protective effect of Vitamin D3 which prevented cadmium- or oleic acid-induced fat storage significantly. In conclusion, this study illustrates the mechanism underlying cadmium-induced lipid accumulation in body through bacterial metabolites and reveals the interplay between environmental cadmium, microorganisms, and the host.
关键词	Cadmium Fat accumulation C elegans Bacteria Oleic acid
收录类别	SCIE ; EI
语种	英语
WOS研究方向	Engineering ; Environmental Sciences & Ecology
WOS类目	Engineering, Environmental ; Environmental Sciences
WOS记录号	WOS:000696935900004
出版者	ELSEVIER
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/128212
专题	生命科学与技术学院_博士生
通讯作者	Ba, Qian; Wang, Hui
作者单位	1.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Shanghai 200025, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, State Key Lab Oncogenes & Related Genes,Ctr Singl, Shanghai 200025, Peoples R China; 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200025, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Ma, Xueqi,Hou, Min,Liu, Chaobao,et al. Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,421.
APA	Ma, Xueqi,Hou, Min,Liu, Chaobao,Li, Jingquan,Ba, Qian,&Wang, Hui.(2022).Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans.JOURNAL OF HAZARDOUS MATERIALS,421.
MLA	Ma, Xueqi,et al."Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans".JOURNAL OF HAZARDOUS MATERIALS 421(2022).