Lung stem cells in regeneration and tumorigenesis

doi:10.1016/j.jgg.2020.12.004

	Lung stem cells in regeneration and tumorigenesis
	Chen, Yuting1,2,3 ; Xue, Yun 1,2; Jin, Yujuan 1,2; Ji, Hongbin1,2,3,4
	2021-04-20
发表期刊	JOURNAL OF GENETICS AND GENOMICS (IF:6.6[JCR-2023],5.8[5-Year])
ISSN	1673-8527
EISSN	1873-5533
卷号	48 期号:4 页码:268-276
DOI	10.1016/j.jgg.2020.12.004
摘要	Adult lung is a highly quiescent organ, with extremely low cell turnover frequency. However, emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various injuries. Lung regeneration mainly depends on the proliferation of regionally distributed pulmonary stem cells that re-enter the cell cycle. Genetic lineage-tracing approaches help to track the lung epithelial differentiation and/or de-differentiation path, and single-cell transcriptomic technique reveals the essential molecular signaling involved in lung regeneration. Dysregulation of the molecular signaling that balances quiescence and self- renewal leads to the transformation of lung stem cells, and thus promotes lung cancer development. Interestingly, different subtypes of lung cancer share common cells of origin and the pathological transition among various subtypes is responsible for drug resistance in the clinic. In this review, we summarize the recent understanding of lung stem cells in regeneration and tumorigenesis as well as related molecular mechanisms, with the hope to provide helpful insights for clinical treatments of respiratory diseases. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
关键词	Lung stem cells Lung cancer Regeneration Tumorigenesis Pathological transition
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:000681048900002
出版者	SCIENCE PRESS
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127943
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_季红斌组
通讯作者	Jin, Yujuan; Ji, Hongbin
作者单位	1.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 4.Tongji Univ, Shanghai Pulm Hosp, Shanghai 200092, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Yuting,Xue, Yun,Jin, Yujuan,et al. Lung stem cells in regeneration and tumorigenesis[J]. JOURNAL OF GENETICS AND GENOMICS,2021,48(4):268-276.
APA	Chen, Yuting,Xue, Yun,Jin, Yujuan,&Ji, Hongbin.(2021).Lung stem cells in regeneration and tumorigenesis.JOURNAL OF GENETICS AND GENOMICS,48(4),268-276.
MLA	Chen, Yuting,et al."Lung stem cells in regeneration and tumorigenesis".JOURNAL OF GENETICS AND GENOMICS 48.4(2021):268-276.