Mitochondrial metabolism regulates macrophage biology

doi:10.1016/j.jbc.2021.100904

	Mitochondrial metabolism regulates macrophage biology
	Wang, Yafang; Li, Na; Zhang, Xin; Horng, Tiffany
	2021-07
发表期刊	JOURNAL OF BIOLOGICAL CHEMISTRY (IF:4.0[JCR-2023],4.4[5-Year])
ISSN	0021-9258
EISSN	1083-351X
卷号	297 期号:1
DOI	10.1016/j.jbc.2021.100904
摘要	Mitochondria are critical for regulation of the activation, differentiation, and survival of macrophages and other immune cells. In response to various extracellular signals, such as microbial or viral infection, changes to mitochondrial metabolism and physiology could underlie the corresponding state of macrophage activation. These changes include alterations of oxidative metabolism, mitochondrial membrane potential, and tricarboxylic acid (TCA) cycling, as well as the release of mitochondrial reactive oxygen species (mtROS) and mitochondrial DNA (mtDNA) and transformation of the mitochondrial ultrastructure. Here, we provide an updated review of how changes in mitochondrial metabolism and various metabolites such as fumarate, succinate, and itaconate coordinate to guide macrophage activation to distinct cellular states, thus clarifying the vital link between mitochondria metabolism and immunity. We also discuss how in disease settings, mitochondrial dysfunction and oxidative stress contribute to dysregulation of the inflammatory response. Therefore, mitochondria are a vital source of dynamic signals that regulate macrophage biology to fine-tune immune responses.
收录类别	SCIE ; EI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000678068400093
出版者	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
原始文献类型	Review
引用统计	被引频次：142[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127863
专题	生命科学与技术学院_博士生免疫化学研究所_特聘教授组_蒋华良组生命科学与技术学院_PI研究组_洪诗雅组
通讯作者	Wang, Yafang; Horng, Tiffany
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Yafang,Li, Na,Zhang, Xin,et al. Mitochondrial metabolism regulates macrophage biology[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2021,297(1).
APA	Wang, Yafang,Li, Na,Zhang, Xin,&Horng, Tiffany.(2021).Mitochondrial metabolism regulates macrophage biology.JOURNAL OF BIOLOGICAL CHEMISTRY,297(1).
MLA	Wang, Yafang,et al."Mitochondrial metabolism regulates macrophage biology".JOURNAL OF BIOLOGICAL CHEMISTRY 297.1(2021).