Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state

doi:10.1016/j.bbrc.2021.05.079

	Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state
	Wang, Hui 1; Yu, Le 1; Qin, Yuan-Jun 1; Chen, Ming2 ; Wang, Xin 3; Luo, Huo-Qing2 ; Cong, Pei-Lin 4; Wang, Xiao-Li 3; Cai, Hong-Miao 1; Zhang, Ai-Lian 1; Juan-Guo 5; Sun, Xiao-Hui 3; Li, Zhao 1; Xue, Ming 1; Sun, Na 1; Wang, Qing-Xiu 1; Hu, Ji2
	2021-08-06
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (IF:2.5[JCR-2023],2.7[5-Year])
ISSN	0006-291X
EISSN	1090-2104
卷号	565 页码:21-28
发表状态	已发表
DOI	10.1016/j.bbrc.2021.05.079
摘要	Preoperative anxiety is common and often comes with a higher probability of worse recovery. However, the neurological mechanism of the effect of preoperative anxiety on general anesthesia and subsequent awakening remains unknown. In this study, we report an anxious state results in delayed awakening in anxiety model mice from sevoflurane general anesthesia. More profound inhibition of DA neurons in the VTA contributes to delayed awakening. Optogenetic stimulation of VTA DA neurons can reverse the delay. The results indicate that VTA DA neurons may be involved in the delay in awakening from general anesthesia caused by anxiety. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
关键词	Anxiety state DA neurons Delayed awakening General anesthesia VTA
收录类别	SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000657000300003
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126922
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_胡霁组
通讯作者	Wang, Qing-Xiu; Hu, Ji
作者单位	1.Tongji Univ, Sch Med, Dept Anesthesiol, East Hosp, Shanghai 200120, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Hosp 9, Dept Anesthesiol, Shanghai 200082, Peoples R China; 4.Tongji Univ, Sch Med, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Shanghai 200120, Peoples R China; 5.Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol, Xian 710000, Shaanxi, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Hui,Yu, Le,Qin, Yuan-Jun,et al. Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2021,565:21-28.
APA	Wang, Hui.,Yu, Le.,Qin, Yuan-Jun.,Chen, Ming.,Wang, Xin.,...&Hu, Ji.(2021).Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,565,21-28.
MLA	Wang, Hui,et al."Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 565(2021):21-28.