The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2

doi:10.1016/j.bbrc.2020.10.091

	The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
	Jin, Zhenming 1,2,3; Wang, Haofeng1,2 ; Duan, Yinkai1 ; Yang, Haitao1
	2021-01-29
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (IF:2.5[JCR-2023],2.7[5-Year])
ISSN	0006-291X
EISSN	1090-2104
卷号	538 页码:63-71
发表状态	已发表
DOI	10.1016/j.bbrc.2020.10.091
摘要	The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M-pro) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of those two key targets above. Different classes of inhibitors individually targeting M-pro and RdRP are discussed, which could promote drug development to treat SARS-CoV-2 infection. (C) 2020 Elsevier Inc. All rights reserved.
关键词	Main protease RNA-dependent RNA polymerase SARS-CoV-2 Inhibitors
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000621177900009
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125855
专题	生命科学与技术学院_硕士生免疫化学研究所生命科学与技术学院_博士生免疫化学研究所_PI研究组_杨海涛组
共同第一作者	Wang, Haofeng; Duan, Yinkai
通讯作者	Wang, Haofeng; Yang, Haitao
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China; 2.Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China; 3.Tsinghua Univ, Sch Med, Beijing, Peoples R China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Jin, Zhenming,Wang, Haofeng,Duan, Yinkai,et al. The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2021,538:63-71.
APA	Jin, Zhenming,Wang, Haofeng,Duan, Yinkai,&Yang, Haitao.(2021).The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,538,63-71.
MLA	Jin, Zhenming,et al."The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 538(2021):63-71.