Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy

doi:10.1016/j.bioorg.2020.104451

	Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy
	Wang, Qiaoqiao1,2,3,4 ; Zhang, Tian 5; Ke, Chang-Qiang 1,2; Tang, Chunping 1,2; Yao, Sheng 1,2; Lin, Ligen 5; Ye, Yang1,2,3,4
	2020-12
发表期刊	BIOORGANIC CHEMISTRY (IF:4.5[JCR-2023],4.7[5-Year])
ISSN	0045-2068
卷号	105
发表状态	已发表
DOI	10.1016/j.bioorg.2020.104451
摘要	Twelve new sesquiterpene lactone dimers, lavandiolides A-L (1-12), were isolated from the whole plants of Artemisia lavandulifolia. Among them, compounds 1-6 are 1,3-linked Diels-Alder adducts between two guaianolide monomers, and 7-12 are 2,4-linked sesquiterpene lactone dimers. Their structures were elucidated by comprehensive analysis of HRESIMS, 1D and 2D NMR spectra. Their absolute configurations were determined by ECD spectra and single-crystal X-ray diffraction analyses with Cu K alpha radiation. The nitric oxide (NO) inhibitory effect of all the isolates was assessed on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Compounds 1, 3, 7 and 9 showed potent inhibitory effects on NO production, with IC50 values of 0.61 +/- 0.15, 1.64 +/- 0.04, 1.89 +/- 0.16, and 1.40 +/- 0.23 uM, respectively. Furthermore, compound 1 inhibited NLRP3 (NOD-, LRRand pyrin domain-containing protein 3) inflammasome-mediated interleukin-1 beta (IL-1 beta) production through activating autophagy.
关键词	Artemisia lavandulifolia Sesquiterpene lactone dimers IL-1 beta NLRP3 Autophagy
收录类别	SCI ; SCIE ; IC
资助项目	National Natural Science Foundation of China[81673327][81903485][81872754][21920102003] ; China National Key RD Program[2017YFE0195100][2018YFC1707000] ; National Science and Technology Major Project[2019ZX09201004-003-042] ; University of Macau[MYRG2017-00109-ICMS][MYRG2018-00037-ICMS]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic
WOS记录号	WOS:000603573500009
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124972
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Lin, Ligen; Ye, Yang
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Qiaoqiao,Zhang, Tian,Ke, Chang-Qiang,et al. Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy[J]. BIOORGANIC CHEMISTRY,2020,105.
APA	Wang, Qiaoqiao.,Zhang, Tian.,Ke, Chang-Qiang.,Tang, Chunping.,Yao, Sheng.,...&Ye, Yang.(2020).Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy.BIOORGANIC CHEMISTRY,105.
MLA	Wang, Qiaoqiao,et al."Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy".BIOORGANIC CHEMISTRY 105(2020).