Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides

doi:10.1016/j.phytochem.2020.112524

	Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides
	Shi, Qing 1; Li, Teng-Teng2,3,4 ; Wu, Yong-Mei 3; Sun, Xin-Yu 3; Lei, Chun 1; Li, Jing-Ya 3,4; Hou, Ai-Jun 1
	2020-12
发表期刊	PHYTOCHEMISTRY (IF:3.2[JCR-2023],3.4[5-Year])
ISSN	0031-9422
卷号	180
发表状态	已发表
DOI	10.1016/j.phytochem.2020.112524
摘要	Eight pairs of meroterpenoid enantiomers and four achiral meroterpenoids were isolated from Rhododendron anthopogonoides Maxim. Seventeen of them, named (+)-/(-)-anthoponoids A-G, (+)-daurichromene D, and anthoponoids H and I, are undescribed compounds with structural diversity. Their structures were characterized herein by a combined application of spectroscopic techniques, X-ray crystallographic analysis, ECD calculation, and the modified Mosher's method. (+)-/(-)-Anthoponoid A and anthoponoid I are the first Rhododendron meroterpenoids found to possess a hexahydroxanthene motif and a diterpene unit, respectively. Some isolates were identified as NF-kappa B pathway inhibitors, and (+)-anthoponoid E, (-)-anthoponoid G, and anthoponoid H showed suppressive effects on LPS-induced inflammatory responses in RAW 264.7 macrophages.
关键词	Rhododendron anthopogonoides Maxim Ericaceae Meroterpenoids Anthoponoids A-I Daurichromene D Anti-inflammation
收录类别	SCI ; SCIE ; IC
语种	英语
资助项目	Fudan-SIMM Joint Research Fund[FU-SIMM20181011]
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号	WOS:000591773300013
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124601
专题	生命科学与技术学院_硕士生
通讯作者	Li, Jing-Ya; Hou, Ai-Jun
作者单位	1.Fudan Univ, Sch Pharm, State Key Lab Med Neurobiol, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Shi, Qing,Li, Teng-Teng,Wu, Yong-Mei,et al. Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides[J]. PHYTOCHEMISTRY,2020,180.
APA	Shi, Qing.,Li, Teng-Teng.,Wu, Yong-Mei.,Sun, Xin-Yu.,Lei, Chun.,...&Hou, Ai-Jun.(2020).Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides.PHYTOCHEMISTRY,180.
MLA	Shi, Qing,et al."Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides".PHYTOCHEMISTRY 180(2020).