Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background

doi:https://doi.org/10.1016/j.scr.2020.101949

	Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background
	Dai,Qiuting; Zhang,Wenxin ; Guo,Jinghui ; Di,Weihao ; Zhao,Jian; Zhang,Bei ; Wang,Ying
	2020-10
发表期刊	STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year])
ISSN	1873-5061
EISSN	1876-7753
卷号	48
发表状态	已发表
DOI	https://doi.org/10.1016/j.scr.2020.101949
摘要	The genotype of apolipoprotein E (APOE) is closely associated with susceptibility to Alzheimer's disease. Here, we described the generation and characterization of human induced pluripotent stem cells from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient with Alzheimer's disease having APOE3/4 genotype. The generated iPSCs expressed pluripotent stem cell markers that were observed using immunocytochemistry. Moreover, they displayed a normal karyotype and had the potential to differentiate spontaneously into three germ layers in vitro. Our model could provide valuable insights into pathological mechanisms,and offer a unique opportunity for developing drugs against specific phenotypes for Alzheimer's disease therapy.
收录类别	SCI
原始文献类型	Article
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123413
专题	生命科学与技术学院_硕士生免疫化学研究所_PI研究组_赵简组
通讯作者	Zhang,Bei; Wang,Ying
作者单位	1.Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China 2.School of Life Science and Technology, ShanghaiTech University, Shanghai, China 3.Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
推荐引用方式 GB/T 7714	Dai,Qiuting,Zhang,Wenxin,Guo,Jinghui,et al. Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background[J]. STEM CELL RESEARCH,2020,48.
APA	Dai,Qiuting.,Zhang,Wenxin.,Guo,Jinghui.,Di,Weihao.,Zhao,Jian.,...&Wang,Ying.(2020).Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background.STEM CELL RESEARCH,48.
MLA	Dai,Qiuting,et al."Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background".STEM CELL RESEARCH 48(2020).