Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background
2020-10
发表期刊STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year])
ISSN1873-5061
EISSN1876-7753
卷号48
发表状态已发表
DOIhttps://doi.org/10.1016/j.scr.2020.101949
摘要

The genotype of apolipoprotein E (APOE) is closely associated with susceptibility to Alzheimer's disease. Here, we described the generation and characterization of human induced pluripotent stem cells from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient with Alzheimer's disease having APOE3/4 genotype. The generated iPSCs expressed pluripotent stem cell markers that were observed using immunocytochemistry. Moreover, they displayed a normal karyotype and had the potential to differentiate spontaneously into three germ layers in vitro. Our model could provide valuable insights into pathological mechanisms,and offer a unique opportunity for developing drugs against specific phenotypes for Alzheimer's disease therapy.

收录类别SCI
原始文献类型Article
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123413
专题生命科学与技术学院_硕士生
免疫化学研究所_PI研究组_赵简组
通讯作者Zhang,Bei; Wang,Ying
作者单位
1.Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China
2.School of Life Science and Technology, ShanghaiTech University, Shanghai, China
3.Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
推荐引用方式
GB/T 7714
Dai,Qiuting,Zhang,Wenxin,Guo,Jinghui,et al. Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background[J]. STEM CELL RESEARCH,2020,48.
APA Dai,Qiuting.,Zhang,Wenxin.,Guo,Jinghui.,Di,Weihao.,Zhao,Jian.,...&Wang,Ying.(2020).Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background.STEM CELL RESEARCH,48.
MLA Dai,Qiuting,et al."Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background".STEM CELL RESEARCH 48(2020).
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