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Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background | |
2020-10 | |
发表期刊 | STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year]) |
ISSN | 1873-5061 |
EISSN | 1876-7753 |
卷号 | 48 |
发表状态 | 已发表 |
DOI | https://doi.org/10.1016/j.scr.2020.101949 |
摘要 | The genotype of apolipoprotein E (APOE) is closely associated with susceptibility to Alzheimer's disease. Here, we described the generation and characterization of human induced pluripotent stem cells from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient with Alzheimer's disease having APOE3/4 genotype. The generated iPSCs expressed pluripotent stem cell markers that were observed using immunocytochemistry. Moreover, they displayed a normal karyotype and had the potential to differentiate spontaneously into three germ layers in vitro. Our model could provide valuable insights into pathological mechanisms,and offer a unique opportunity for developing drugs against specific phenotypes for Alzheimer's disease therapy. |
收录类别 | SCI |
原始文献类型 | Article |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123413 |
专题 | 生命科学与技术学院_硕士生 免疫化学研究所_PI研究组_赵简组 |
通讯作者 | Zhang,Bei; Wang,Ying |
作者单位 | 1.Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China 2.School of Life Science and Technology, ShanghaiTech University, Shanghai, China 3.Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China |
推荐引用方式 GB/T 7714 | Dai,Qiuting,Zhang,Wenxin,Guo,Jinghui,et al. Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background[J]. STEM CELL RESEARCH,2020,48. |
APA | Dai,Qiuting.,Zhang,Wenxin.,Guo,Jinghui.,Di,Weihao.,Zhao,Jian.,...&Wang,Ying.(2020).Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background.STEM CELL RESEARCH,48. |
MLA | Dai,Qiuting,et al."Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79- year-old patient with Alzheimer’s disease having APOE3/4 genetic background".STEM CELL RESEARCH 48(2020). |
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