Inhibitory synaptic transmission tuned by Ca2+ and glutamate through the control of GABA(A)R lateral diffusion dynamics

doi:10.1111/dgd.12667

KMS > 免疫化学研究所 > PI研究组 > Katsuhiko Mikoshiba组

	Inhibitory synaptic transmission tuned by Ca2+ and glutamate through the control of GABA(A)R lateral diffusion dynamics
	Bannai, Hiroko 1,2,3,4; Niwa, Fumihiro 4,5; Sakuragi, Shigeo 1,6; Mikoshiba, Katsuhiko4,7,8
	2020-05-20
发表期刊	DEVELOPMENT GROWTH & DIFFERENTIATION
ISSN	0012-1592
EISSN	1440-169X
发表状态	已发表
DOI	10.1111/dgd.12667
摘要	The GABAergic synapses, a primary inhibitory synapse in the mammalian brain, is important for the normal development of brain circuits, and for the regulation of the excitation-inhibition balance critical for brain function from the developmental stage throughout life. However, the molecular mechanism underlying the formation, maintenance, and modulation of GABAergic synapses is less understood compared to that of excitatory synapses. Quantum dot-single particle tracking (QD-SPT), a super-resolution imaging technique that enables the analysis of membrane molecule dynamics at single-molecule resolution, is a powerful tool to analyze the behavior of proteins and lipids on the plasma membrane. In this review, we summarize the recent application of QD-SPT in understanding of GABAergic synaptic transmission. Here we introduce QD-SPT experiments that provide further insights into the molecular mechanism supporting GABAergic synapses. QD-SPT studies revealed that glutamate and Ca2+ signaling is involved in (a) the maintenance of GABAergic synapses, (b) GABAergic long-term depression, and GABAergic long-term potentiation, by specifically activating signaling pathways unique to each phenomenon. We also introduce a novel Ca2+ imaging technique to describe the diversity of Ca2+ signals that may activate the downstream signaling pathways that induce specific biological output.
收录类别	SCI ; SCIE
语种	英语
资助项目	PRESTO-JST[JPMJPR15F8] ; MEXT[JP17H05710][JP18H05414] ; JSPS[JP16K07316]
WOS研究方向	Cell Biology ; Developmental Biology
WOS类目	Cell Biology ; Developmental Biology
WOS记录号	WOS:000534170200001
出版者	WILEY
WOS关键词	RECEPTOR ; SYNAPSES ; TRAFFICKING ; PLASTICITY ; SUBUNITS ; POTENTIATION ; CALCINEURIN ; ACTIVATION ; INSIGHTS ; MOBILITY
原始文献类型	Review ; Early Access
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121085
专题	免疫化学研究所_PI研究组_Katsuhiko Mikoshiba组
通讯作者	Bannai, Hiroko
作者单位	1.Waseda Univ, Sch Adv Sci & Engn, Dept Elect Engn & Biosci, Tokyo, Japan 2.Keio Univ, Dept Neurophysiol, Sch Med, Tokyo, Japan 3.Japan Sci & Technol Agcy, PRESTO, Saitama, Japan 4.RIKEN Ctr Brain Sci, Lab Dev Neurobiol, Wako, Saitama, Japan 5.PSL Res Univ, Inst Biol ENS IBENS, CNRS, INSERM,Ecole Normale Super, Paris, France 6.Yamagata Univ, Fac Med, Dept Pharmacol, Yamagata, Japan 7.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Shanghai, Peoples R China 8.Toho Univ, Fac Sci, Dept Biomol Sci, Funabashi, Chiba, Japan
推荐引用方式 GB/T 7714	Bannai, Hiroko,Niwa, Fumihiro,Sakuragi, Shigeo,et al. Inhibitory synaptic transmission tuned by Ca2+ and glutamate through the control of GABA(A)R lateral diffusion dynamics[J]. DEVELOPMENT GROWTH & DIFFERENTIATION,2020.
APA	Bannai, Hiroko,Niwa, Fumihiro,Sakuragi, Shigeo,&Mikoshiba, Katsuhiko.(2020).Inhibitory synaptic transmission tuned by Ca2+ and glutamate through the control of GABA(A)R lateral diffusion dynamics.DEVELOPMENT GROWTH & DIFFERENTIATION.
MLA	Bannai, Hiroko,et al."Inhibitory synaptic transmission tuned by Ca2+ and glutamate through the control of GABA(A)R lateral diffusion dynamics".DEVELOPMENT GROWTH & DIFFERENTIATION (2020).