Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI

doi:10.1016/j.neuroimage.2020.116664

KMS > iHuman研究所 > PI研究组 > Garth John Thompson组

	Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI
	Sanganahalli, Basavaraju G.1,2,3; Baker, Keeley L.4,5; Thompson, Garth J.1,7 ; Herman, Peter 1,2,3; Shepherd, Gordon M.4; Verhagen, Justus V.4,5; Hyder, Fahmeed 1,2,3,6
	2020-05-15
发表期刊	NEUROIMAGE
ISSN	1053-8119
EISSN	1095-9572
卷号	212
发表状态	已发表
DOI	10.1016/j.neuroimage.2020.116664
摘要	Odorants can reach olfactory receptor neurons (ORNs) by two routes: orthonasally, when volatiles enter the nasal cavity during inhalation/sniffing, and retronasally, when food volatiles released in the mouth pass into the nasal cavity during exhalation/eating. Previous work in humans has shown that both delivery routes of the same odorant can evoke distinct perceptions and patterns of neural responses in the brain. Each delivery route is known to influence specific responses across the dorsal region of the glomerular sheet in the olfactory bulb (OB), but spatial distributions across the entire glomerular sheet throughout the whole OB remain largely unexplored. We used functional MRI (fMRI) to measure and compare activations across the entire glomerular sheet in rat OB resulting from both orthonasal and retronasal stimulations of the same odors. We observed reproducible fMRI activation maps of the whole OB during both orthonasal and retronasal stimuli. However, retronasal stimuli required double the orthonasal odor concentration for similar response amplitudes. Regardless, both the magnitude and spatial extent of activity were larger during orthonasal versus retronasal stimuli for the same odor. Orthonasal and retronasal response patterns show overlap as well as some route-specific dominance. Orthonasal maps were dominant in dorsal-medial regions, whereas retronasal maps were dominant in caudal and lateral regions. These different whole OB encodings likely underlie differences in odor perception between these biologically important routes for odorants among mammals. These results establish the relationships between orthonasal and retronasal odor representations in the rat OB.
关键词	Retronasal Orthonasal Olfactory bulb Glomeruli fMRI
收录类别	SCI ; SCIE
语种	英语
资助项目	NIH[R01 MH-067528] ; NIH[P30 NS-052519]
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000525320500018
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	RECEPTOR NEURON INPUT ; ACTIVITY PATTERNS ; ODOR MAPS ; FUNCTIONAL MRI ; RESPONSES ; REPRESENTATIONS ; PERCEPTION ; DISCRIMINATION ; BRAIN ; DYNAMICS
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119384
专题	iHuman研究所_PI研究组_Garth John Thompson组
通讯作者	Sanganahalli, Basavaraju G.; Hyder, Fahmeed
作者单位	1.Yale Univ, Magnet Resonance Res Ctr, New Haven, CT 06520 USA 2.Yale Univ, Quantitat Neurosci Magnet Resonance QNMR Core Ctr, New Haven, CT 06520 USA 3.Yale Univ, Dept Radiol & Biomed Imaging, New Haven, CT 06520 USA 4.Yale Univ, Dept Neurosci, New Haven, CT 06520 USA 5.John B Pierce Lab, New Haven, CT USA 6.Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA 7.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Sanganahalli, Basavaraju G.,Baker, Keeley L.,Thompson, Garth J.,et al. Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI[J]. NEUROIMAGE,2020,212.
APA	Sanganahalli, Basavaraju G..,Baker, Keeley L..,Thompson, Garth J..,Herman, Peter.,Shepherd, Gordon M..,...&Hyder, Fahmeed.(2020).Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI.NEUROIMAGE,212.
MLA	Sanganahalli, Basavaraju G.,et al."Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI".NEUROIMAGE 212(2020).