The emerging roles of the DDX41 protein in immunity and diseases

doi:10.1007/s13238-016-0303-4

	The emerging roles of the DDX41 protein in immunity and diseases
	Jiang, Yan 1; Zhu, Yanping 1; Liu, Zhi-Jie1,2 ; Ouyang, Songying 1,3
	2017-02
发表期刊	PROTEIN & CELL
ISSN	1674-800X
卷号	8 期号:2 页码:83-89
发表状态	已发表
DOI	10.1007/s13238-016-0303-4
摘要	RNA helicases are involved in almost every aspect of RNA, from transcription to RNA decay. DExD/H-box helicases comprise the largest SF2 helicase superfamily, which are characterized by two conserved RecA-like domains. In recent years, an increasing number of unexpected functions of these proteins have been discovered. They play important roles not only in innate immune response but also in diseases like cancers and chronic hepatitis C. In this review, we summarize the recent literatures on one member of the SF2 superfamily, the DEAD-box protein DDX41. After bacterial or viral infection, DNA or cyclic-di-GMP is released to cells. After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons (IFN). After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. Besides the roles in innate immunity, DDX41 is also related to diseases. An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (MDS/AML) patients. The review focuses on DDX41, as well as its homolog Abstrakt in Drosophila, which is important for survival at all stages throughout the life cycle of the fly.
关键词	DDX41 innate immunity RNA helicases myelodysplastic syndrome acute myeloid leukemia
收录类别	SCI
语种	英语
资助项目	Youth Innovation Promotion Association CAS[2013065]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000394146000002
出版者	HIGHER EDUCATION PRESS
WOS关键词	DEAD-BOX PROTEIN ; CYCLIC DI-GMP ; ACUTE MYELOID-LEUKEMIA ; STING ADAPTER PROTEIN ; DENDRITIC CELLS ; RNA HELICASES ; I-TASSER ; REPLICATION ; MUTATIONS ; ABSTRAKT
原始文献类型	Review
引用统计	被引频次：71[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1057
专题	iHuman研究所_PI研究组_刘志杰组 iHuman研究所
通讯作者	Ouyang, Songying
作者单位	1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Shanghai Tech Univ, iHuman Inst, Shanghai 201210, Peoples R China 3.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
推荐引用方式 GB/T 7714	Jiang, Yan,Zhu, Yanping,Liu, Zhi-Jie,et al. The emerging roles of the DDX41 protein in immunity and diseases[J]. PROTEIN & CELL,2017,8(2):83-89.
APA	Jiang, Yan,Zhu, Yanping,Liu, Zhi-Jie,&Ouyang, Songying.(2017).The emerging roles of the DDX41 protein in immunity and diseases.PROTEIN & CELL,8(2),83-89.
MLA	Jiang, Yan,et al."The emerging roles of the DDX41 protein in immunity and diseases".PROTEIN & CELL 8.2(2017):83-89.