Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II
Liu, Keli1,2; Lin, Liangyu1; Li, Qing1; Xue, Yueqing1; Zheng, Fanjun1; Wang, Guan1; Zheng, Chunxing1; Du, Liming1; Hu, Mingyuan1; Huang, Yin1
2020-02-04
发表期刊PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
卷号117期号:5页码:2462-2472
发表状态已发表
DOI10.1073/pnas.1914553117
摘要

Preadipocytes can give rise to either white adipocytes or beige adipocytes. Owing to their distinct abilities in nutrient storage and energy expenditure, strategies that specifically promote "beiging" of adipocytes hold great promise for counterbalancing obesity and metabolic diseases. Yet, factors dictating the differentiation fate of adipocyte progenitors remain to be elucidated. We found that stearoyl-coenzyme A desaturase 1 (Scd1)-deficient mice, which resist metabolic stress, possess augmentation in beige adipocytes under basal conditions. Deletion of Scd1 in mature adipocytes expressing Fabp4 or Ucp1 did not affect thermogenesis in mice. Rather, Scd1 deficiency shifted the differentiation fate of preadipocytes from white adipogenesis to beige adipogenesis. Such effects are dependent on succinate accumulation in adipocyte progenitors, which fuels mitochondrial complex II activity. Suppression of mitochondrial complex II by Atpenin A5 or oxaloacetic acid reverted the differentiation potential of Scd1-deficient preadipocytes to white adipocytes. Furthermore, supplementation of succinate was found to increase beige adipocyte differentiation both in vitro and in vivo. Our data reveal an unappreciated role of Scd1 in determining the cell fate of adipocyte progenitors through succinate-dependent regulation of mitochondrial complex II.

关键词stearoyl-coenzyme A desaturase 1 (Scd1) beige fat biogenesis preadipocytes succinate mitochondrial complex II
收录类别SCI ; SCIE
语种英语
资助项目Ministry of Foreign Affairs and International Cooperation Italy-China Science and Technology Cooperation[PGR00961]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000512340900038
出版者NATL ACAD SCIENCES
WOS关键词STEAROYL-COA DESATURASE-1 ; DEFICIENCY PROTECTS MICE ; ADIPOSE-TISSUE ; BROWN ADIPOCYTES ; ENERGY ; GENE ; CELL ; ADIPOGENESIS ; METABOLISM ; WEIGHT
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/105325
专题生命科学与技术学院_博士生
生命科学与技术学院
通讯作者Shi, Yufang; Wang, Ying
作者单位1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci,CAS Key Lab Tissue Microen, Shanghai 200031, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
3.Soochow Univ, Inst Translat Med, State Key Lab Radiat Med & Protect, Affiliated Hosp 1, Suzhou 215123, Peoples R China
4.Ist Dermopat Immacolata IDI IRCCS, Biochem Lab, I-00100 Rome, Italy
5.Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Liu, Keli,Lin, Liangyu,Li, Qing,et al. Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2020,117(5):2462-2472.
APA Liu, Keli.,Lin, Liangyu.,Li, Qing.,Xue, Yueqing.,Zheng, Fanjun.,...&Wang, Ying.(2020).Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,117(5),2462-2472.
MLA Liu, Keli,et al."Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117.5(2020):2462-2472.
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