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Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration | |
2020-01 | |
发表期刊 | CELL STEM CELL |
ISSN | 1934-5909 |
EISSN | 1875-9777 |
卷号 | 26期号:1页码:81-+ |
发表状态 | 已发表 |
DOI | 10.1016/j.stem.2019.11.010 |
摘要 | Rapid regeneration of smooth muscle after vascular injury is essential for maintaining arterial function. The existence and putative roles of resident vascular stem cells (VSCs) in artery repair are controversial, and vessel regeneration is thought to be mediated by proliferative expansion of pre-existing smooth muscle cells (SMCs). Here, we performed cell fate mapping and single-cell RNA sequencing to identify Sca1(+) VSCs in the adventitial layer of artery walls. After severe injury, Sca1(+) VSCs migrate into the medial layer and generate de novo SMCs, which subsequently expand more efficiently compared with preexisting smooth muscle. Genetic lineage tracing using dual recombinases distinguished a Sca1(+)PDGFRa(+) VSC subpopulation that generates SMCs, and genetic ablation of Sca1(+) VSCs or specific knockout of Yap1 in Sca1(+) VSCs significantly impaired artery repair. These findings provide genetic evidence of a bona fide Sca1(+) VSC population that produces SMCs and delineates their critical role in vessel repair. |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | Major Program of the Development Fund for the Shanghai Zhangjiang National Innovation Demonstration Zone (Stem Cell Clinical Technology Transformation Platform)[ZJ2018-ZD-004] |
WOS研究方向 | Cell Biology |
WOS类目 | Cell & Tissue Engineering ; Cell Biology |
WOS记录号 | WOS:000505213700010 |
出版者 | CELL PRESS |
WOS关键词 | DIPHTHERIA-TOXIN RECEPTOR ; CARDIAC NEURAL CREST ; PROGENITOR CELLS ; MESENCHYMAL TRANSITION ; NEOINTIMAL FORMATION ; ENDOTHELIAL-CELLS ; ORIGIN ; ATHEROSCLEROSIS ; CONTRIBUTE ; AORTA |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/105113 |
专题 | 生命科学与技术学院_硕士生 生命科学与技术学院_特聘教授组_周斌组 |
通讯作者 | Zhang, Li; Gao, Dong; Zhou, Bin |
作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain 4.Aarhus Univ, Deparment Clin Med, Aarhus, Denmark 5.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Minist Educ, Tianjin 300070, Peoples R China 6.Tianjin Med Univ, Tianjin Key Lab Inflammatory Biol, Key Lab Immune Microenvironment & Dis, Minist Educ, Tianjin 300070, Peoples R China 7.Nanjing Med Univ, Key Lab Cardiovasc & Cerebrovasc Med, Nanjing 211100, Jiangsu, Peoples R China 8.Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Me, Nanjing 211100, Jiangsu, Peoples R China 9.Chinese Acad Med Sci, State Key Lab Cardiovasc Dis, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China 10.Peking Union Med Coll, Beijing, Peoples R China 11.Jinan Univ, Minist Educ, Key Lab Regenerat Med, Guangzhou 510632, Guangdong, Peoples R China 12.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China 13.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Tang, Juan,Wang, Haixiao,Huang, Xiuzhen,et al. Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration[J]. CELL STEM CELL,2020,26(1):81-+. |
APA | Tang, Juan.,Wang, Haixiao.,Huang, Xiuzhen.,Li, Fei.,Zhu, Huan.,...&Zhou, Bin.(2020).Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration.CELL STEM CELL,26(1),81-+. |
MLA | Tang, Juan,et al."Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration".CELL STEM CELL 26.1(2020):81-+. |
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