消息
×
loading..
Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
2019-12-11
发表期刊NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
ISSN2041-1723
卷号10
发表状态已发表
DOI10.1038/s41467-019-13605-4
摘要Organoids have extensive therapeutic potential and are increasingly opening up new avenues within regenerative medicine. However, their clinical application is greatly limited by the lack of effective GMP-compliant systems for organoid expansion in culture. Here, we envisage that the use of extracellular matrix (ECM) hydrogels derived from decellularized tissues (DT) can provide an environment capable of directing cell growth. These gels possess the biochemical signature of tissue-specific ECM and have the potential for clinical translation. Gels from decellularized porcine small intestine (SI) mucosa/submucosa enable formation and growth of endoderm-derived human organoids, such as gastric, hepatic, pancreatic, and SI. ECM gels can be used as a tool for direct human organoid derivation, for cell growth with a stable transcriptomic signature, and for in vivo organoid delivery. The development of these ECM-derived hydrogels opens up the potential for human organoids to be used clinically.
URL查看原文
收录类别SCI ; SCIE
语种英语
资助项目[F-0301-15-009]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000502104400001
出版者NATURE PUBLISHING GROUP
WOS关键词SMALL-INTESTINAL SUBMUCOSA ; LONG-TERM EXPANSION ; STEM-CELLS ; IN-VITRO ; EXPRESSION ; COLON ; IDENTIFICATION ; ARCHITECTURE ; EPITHELIUM ; GROWTH
原始文献类型Article
引用统计
被引频次:352[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/104869
专题免疫化学研究所_特聘教授组_生物工程学实验室
生命科学与技术学院_硕士生
通讯作者Elvassore, Nicola; De Coppi, Paolo
作者单位
1.UCL, GOS Inst Child Hlth, Stem Cell & Regenerat Med Sect, London, England
2.ShanghaiTech Univ, SIAIS, Shanghai, Peoples R China
3.Francis Crick Inst, Epithelial Stem Cell Biol & Regenerat Med Lab, London, England
4.Royal Netherlands Acad Arts & Sci KNAW, Hubrecht Inst, Oncode Inst, Utrecht, Netherlands
5.Univ Med Ctr UMC Utrecht, Utrecht, Netherlands
6.Francis Crick Inst, Stem Cell & Canc Biol Lab, London, England
7.Telethon Inst Genet & Med TIGEM, Pozzuoli, Italy
8.Univ Padua, Veneto Inst Mol Med, Padua, Italy
9.Univ Padua, Dept Ind Engn, Padua, Italy
10.Princess Maxima Ctr PMC Pediat Oncol, Utrecht, Netherlands
11.Great Ormond St Hosp Sick Children, Specialist Neonatal & Paediat Surg Unit, London, England
通讯作者单位上海科技大学
推荐引用方式
GB/T 7714
Giobbe, Giovanni Giuseppe,Crowley, Claire,Luni, Camilla,et al. Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture[J]. NATURE COMMUNICATIONS,2019,10.
APA Giobbe, Giovanni Giuseppe.,Crowley, Claire.,Luni, Camilla.,Campinoti, Sara.,Khedr, Moustafa.,...&De Coppi, Paolo.(2019).Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture.NATURE COMMUNICATIONS,10.
MLA Giobbe, Giovanni Giuseppe,et al."Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture".NATURE COMMUNICATIONS 10(2019).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Giobbe, Giovanni Giuseppe]的文章
[Crowley, Claire]的文章
[Luni, Camilla]的文章
百度学术
百度学术中相似的文章
[Giobbe, Giovanni Giuseppe]的文章
[Crowley, Claire]的文章
[Luni, Camilla]的文章
必应学术
必应学术中相似的文章
[Giobbe, Giovanni Giuseppe]的文章
[Crowley, Claire]的文章
[Luni, Camilla]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10.1038@s41467-019-13605-4.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。