Histamine H-1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour

doi:10.1038/s41598-019-52623-6

KMS > 免疫化学研究所 > PI研究组 > Katsuhiko Mikoshiba组

	Histamine H-1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour
	Karpati, Aniko 1; Yoshikawa, Takeo 1; Naganuma, Fumito 1,2; Matsuzawa, Takuro 1; Kitano, Haruna 1; Yamada, Yo 1; Yokoyama, Mariko 1; Futatsugi, Akira 3; Mikoshiba, Katsuhiko4 ; Yanai, Kazuhiko 1
	2019-11-11
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	9
发表状态	已发表
DOI	10.1038/s41598-019-52623-6
摘要	Histamine is an important neurotransmitter that contributes to various processes, including the sleep-wake cycle, learning, memory, and stress responses. Its actions are mediated through histamine H-1-H-4 receptors. Gene knockout and pharmacological studies have revealed the importance of H-1 receptors in learning and memory, regulation of aggression, and wakefulness. H-1 receptors are abundantly expressed on neurons and astrocytes. However, to date, studies selectively investigating the roles of neuronal and astrocytic H-1 receptors in behaviour are lacking. We generated novel astrocyte- and neuron-specific conditional knockout (cKO) mice to address this gap in knowledge. cKO mice showed cell-specific reduction of H-1 receptor gene expression. Behavioural assessment revealed significant changes and highlighted the importance of H-1 receptors on both astrocytes and neurons. H-1 receptors on both cell types played a significant role in anxiety. Astrocytic H-1 receptors were involved in regulating aggressive behaviour, circadian rhythms, and quality of wakefulness, but not sleep behaviour. Our results emphasise the roles of neuronal H-1 receptors in recognition memory. In conclusion, this study highlights the novel roles of H-1 receptors on astrocytes and neurons in various brain functions.
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收录类别	SCI ; SCIE
语种	英语
资助项目	JSPS[18J11446] ; JSPS[18K06886]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000495611100043
出版者	NATURE PUBLISHING GROUP
WOS关键词	LOCOMOTOR-ACTIVITY ; MICE ; ACTIVATION ; H1 ; H1-RECEPTOR ; MECHANISM ; INSIGHTS ; MEMORY
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102238
专题	免疫化学研究所_PI研究组_Katsuhiko Mikoshiba组
通讯作者	Yoshikawa, Takeo
作者单位	1.Tohoku Univ, Grad Sch Med, Dept Pharmacol, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan 2.Tohoku Med & Pharmaceut Univ, Fac Med, Div Pharmacol, Miyagino Ku, 1-15-1 Fukumuro, Sendai, Miyagi 9838536, Japan 3.Kobe City Coll Nursing, Dept Basic Med Sci, Nishi Ku, 3-4 Gakuen Nishi Machi, Kobe, Hyogo 6512103, Japan 4.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Karpati, Aniko,Yoshikawa, Takeo,Naganuma, Fumito,et al. Histamine H-1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour[J]. SCIENTIFIC REPORTS,2019,9.
APA	Karpati, Aniko.,Yoshikawa, Takeo.,Naganuma, Fumito.,Matsuzawa, Takuro.,Kitano, Haruna.,...&Yanai, Kazuhiko.(2019).Histamine H-1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour.SCIENTIFIC REPORTS,9.
MLA	Karpati, Aniko,et al."Histamine H-1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour".SCIENTIFIC REPORTS 9(2019).