Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23

doi:10.1038/s41467-018-06372-1

	Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
	Xu, Yu 1; Sun, Yang 1; Shen, Hao 1; Dai, Yuling 1; Liu, Haifeng 1; Li, Ronghong 1; Zhang, Hongdao 1; Wu, Ligang 1; Zhu, Xiaoyan 1; Liu, Xiaolong1,2
	2018-09-24
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	9
发表状态	已发表
DOI	10.1038/s41467-018-06372-1
摘要	Invariant natural killer T cells (iNKT cells) are a specific subset of T cells that recognize glycolipid antigens and upon activation rapidly exert effector functions. This unique function is established during iNKT cell development; the detailed mechanisms of this process, however, remain to be elucidated. Here the authors show that deletion of the mediator subunit Med23 in CD4(+)CD8(+) double positive (DP) thymocytes completely blocks iNKT cell development at stage 2. This dysregulation is accompanied by a bias in the expression of genes related to the regulation of transcription and metabolism, and functional impairment of the cells including the loss of NK cell characteristics, reduced ability to secrete cytokines and attenuated recruitment capacity upon activation. Moreover, Med23-deficient iNKT cells exhibit impaired anti-tumor activity. Our study identifies Med23 as an essential transcriptional regulator that controls iNKT cell differentiation and terminal maturation.
收录类别	SCI ; SCIE
语种	英语
资助项目	China Postdoctoral Science Foundation[2015M581672]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000445329000010
出版者	NATURE PUBLISHING GROUP
WOS关键词	KILLER T-CELLS ; NATURAL-KILLER ; NKT CELLS ; TRANSCRIPTIONAL CONTROL ; IFN-GAMMA ; LINEAGE ; MED23 ; DIFFERENTIATION ; ACTIVATION ; EXPRESSION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27788
专题	生命科学与技术学院_特聘教授组_刘小龙组
通讯作者	Liu, Xiaolong
作者单位	1.Univ Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol,Chinese Acad Sc, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Xu, Yu,Sun, Yang,Shen, Hao,et al. Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23[J]. NATURE COMMUNICATIONS,2018,9.
APA	Xu, Yu.,Sun, Yang.,Shen, Hao.,Dai, Yuling.,Liu, Haifeng.,...&Liu, Xiaolong.(2018).Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.NATURE COMMUNICATIONS,9.
MLA	Xu, Yu,et al."Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23".NATURE COMMUNICATIONS 9(2018).