ShanghaiTech University Knowledge Management System
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries | |
Tian, Xueying; Hu, Tianyuan; Zhang, Hui; He, Lingjuan; Huang, Xiuzhen; Liu, Qiaozhen; Yu, Wei; He, Liang; Yang, Zhongzhou; Zhang, Zhen; Zhong, Tao P.; Yang, Xiao; Yang, Zhen; Yan, Yan; Baldini, Antonio; Sun, Yunfu; Lu, Jie; Schwartz, Robert J.; Evans, Sylvia M.; Gittenberger-de Groot, Adriana C.; Red-Horse, Kristy; Zhou, Bin
| |
2013 | |
发表期刊 | CELL RESEARCH |
ISSN | 1001-0602 |
卷号 | 23期号:9页码:1075-1090 |
发表状态 | 已发表 |
DOI | 10.1038/cr.2013.83 |
摘要 | Coronary arteries bring blood flow to the heart muscle. Understanding the developmental program of the coronary arteries provides insights into the treatment of coronary artery diseases. Multiple sources have been described as contributing to coronary arteries including the proepicardium, sinus venosus (SV), and endocardium. However, the developmental origins of coronary vessels are still under intense study. We have produced a new genetic tool for studying coronary development, an AplnCreER mouse line, which expresses an inducible Cre recombinase specifically in developing coronary vessels. Quantitative analysis of coronary development and timed induction of AplnCreER fate tracing showed that the progenies of subepicardial endothelial cells (ECs) both invade the compact myocardium to form coronary arteries and remain on the surface to produce veins. We found that these subepicardial ECs are the major sources of intramyocardial coronary vessels in the developing heart. In vitro explant assays indicate that the majority of these subepicardial ECs arise from endocardium of the SV and atrium, but not from ventricular endocardium. Clonal analysis of Apln-positive cells indicates that a single subepicardial EC contributes equally to both coronary arteries and veins. Collectively, these data suggested that subepicardial ECs are the major source of intramyocardial coronary arteries in the ventricle wall, and that coronary arteries and veins have a common origin in the developing heart. |
关键词 | coronary artery origin development subepicardial endothelial cell angiogenesis |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000323930200007 |
WOS关键词 | EPICARDIAL PROGENITORS ; ENDOCARDIAL CELLS ; IN-VIVO ; HEART ; EXPRESSION ; LINEAGE ; MOUSE ; FATE ; VASCULATURE ; REPORTER |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119994 |
专题 | 个人在本单位外知识产出 |
共同第一作者 | Hu, Tianyuan; Zhang, Hui |
通讯作者 | Zhou, Bin |
作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Nanjing Univ, Model Anim Res Ctr, Nanjing 210061, Jiangsu, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Shanghai 200092, Peoples R China 4.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China 5.Inst Biotechnol, State Key Lab Prote, Beijing 100071, Peoples R China 6.Fudan Univ, Zhongshan Hosp, Shanghai 200032, Peoples R China 7.Univ Naples Federico II, Inst Genet & Biophys CNR, I-80138 Naples, Italy 8.Tongji Univ, Sch Med, Shanghai 201000, Peoples R China 9.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China 10.Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA 11.Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA 12.Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands 13.Stanford Univ, Sch Med, Dept Biol, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Tian, Xueying,Hu, Tianyuan,Zhang, Hui,et al. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries[J]. CELL RESEARCH,2013,23(9):1075-1090. |
APA | Tian, Xueying.,Hu, Tianyuan.,Zhang, Hui.,He, Lingjuan.,Huang, Xiuzhen.,...&Zhou, Bin.(2013).Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.CELL RESEARCH,23(9),1075-1090. |
MLA | Tian, Xueying,et al."Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries".CELL RESEARCH 23.9(2013):1075-1090. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。