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Zhang Hui Assistant Professor, PI
Institute: School of Life Science and Technology
Research Fields: Cardiovascular development and diseases
Contact email: Private
Notes: --
Zhang Hui

Research Contents

Our Lab concentrates on the research of cardiac development and cardiomyocyte regeneration. The cardiomyocytes of adult mammalian animals have limited proliferation ability. Cardiomyocyte loss and fibrosis formation after cardiac injury (such as myocardial infarction) will result in heart failure and even death. However, the embryonic and neonatal cardiomyocytes have a strong ability to proliferate, which facilitates the regeneration of embryonic or neonatal hearts. We are interested in the following two questions: (1) What is the reason for the gradual loss of cardiac regeneration capacity? (2) How to improve the adult heart regeneration and repair abilities?
At present, we have generated a variety of mouse genetic tools and developed different disease models (such as myocardial infarction and apex resection). Utilizing lineage tracing and tissue-specific gene manipulation, we are to discover cell fate conversions of different cell types (such as cardiomyocyte progenitor cells, coronary endothelial cells, mesenchymal cells) and their molecular mechanisms during cardiovascular development, pathogenesis and regeneration. Our goals are to develop new potential treatment targets and improve repair and regeneration abilities of cardiovascular system.

Biography

2004.09-2008.06, B.A. in College of Animal Sciences and Technology, Huazhong Agriculture University;
2008.09-2014.03, Ph.D. in Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;
2014.04-2016.03, Postdoc in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;
2016.04-2016.10, Research fellow in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;
2016.11 to Present, Assistant Professor, PI in School of Life Science and Technology, ShanghaiTech University.
        My previous work focused on cardiac development, especially endocardial development. Taking advantage of genetic lineage tracing, we identified the multipotency of embryonic endocardial endothelial cells, which could differentiate into cushion mesenchymal cells (Zhang et al, J Biol Chem, 2014), coronary endothelial cells (Tian et al, Cell Res, 2013; Tian et al, Science, 2014; Zhang et al, Circ Res, 2016), hepatic vascular endothelial cells (Zhang et al, Nat Genet, 2016), intramyocardial adipocytes (Zhang et al, Circ Res, 2016), and coronary mural cells (Chen et al, 2016, Nat Commun).

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