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Inhibitor Development for α‑Synuclein Fibril's Disordered Region to Alleviate Parkinson's Disease Pathology
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 41, 页码: 28282-28295
作者:
Zhang, Shenqing
;
Xiang, Huaijiang
;
Tao, Youqi
;
Li, Juan
;
Zeng, Shuyi
Adobe PDF(12245Kb)
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浏览/下载:361/12
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提交时间:2024/09/27
Neurodegenerative diseases
Nuclear magnetic resonance spectroscopy
Targeted drug delivery
Amyloid fibril
Disordered regions
EM techniques
High throughput screening
Intrinsically disordered regions
Membrane receptors
Pathological effects
Solid state NMR
Structure-activity relationships
α-synuclein
Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 35, 页码: e2321633121
作者:
Liu, Kaien
;
Tao, Youqi
;
Zhao, Qiuyue
;
Xia, Wencheng
;
Li, Xiang
Adobe PDF(12416Kb)
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浏览/下载:360/10
|
提交时间:2024/08/26
alpha- synuclein
amyloid fibril
polymorphism
protein-ligand interaction
chemical ligands
Peptide backbone-copper ring structure: A molecular insight into copper-induced amyloid toxicity (vol 31, 108702, 2022)
其他
CHINESE PHYSICS B, 2023-05-01, 卷号: 32, 期号: 6
作者:
Wang, Jing
;
Jiang, Xiankai
;
Su, Xiurong
;
Zhou, Xingfei
;
Wang, Yu
Adobe PDF(3737Kb)
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收藏
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浏览/下载:396/1
|
提交时间:2023/06/26
interactions between metal ion and protein
quantum chemistry calculation
protein aggregation
amyloid diseases
The necessary of ternary amyloid classification for clinical practice: An alternative to the binary amyloid definition
期刊论文
VIEW, 2023, 卷号: 4, 期号: 5
作者:
Ren, Shuhua
;
Pan, Yongsheng
;
Li, Junpeng
;
Huang, Lin
;
Cui, Liang
Adobe PDF(1589Kb)
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收藏
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浏览/下载:316/0
|
提交时间:2023/03/17
Deep learning
Deposition
Glucose
Glycoproteins
Learning systems
Metabolism
Neurodegenerative diseases
Positron emission tomography
Proteins
Amyloid deposition
Clinical practices
Cognitive performance
Deep learning
Equivocal amyloid deposition
Glucose metabolism
Learning methods
Neurodegeneration
Standardized uptake values
Individualized assessment of brain A deposition with fMRI using deep learning
期刊论文
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 2023, 卷号: PP, 期号: 99, 页码: 1-12
作者:
Li, Chaolin
;
Liu, Mianxin
;
Xia, Jing
;
Mei, Lang
;
Yang, Qing
Adobe PDF(2993Kb)
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收藏
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浏览/下载:296/1
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提交时间:2023/09/08
Bioinformatics
Biomarkers
Classification (of information)
Convolution
Deposition
Diagnosis
Forestry
Magnetic resonance imaging
Mean square error
Medical imaging
Amyloid β
Brain modeling
Convolutional networks
Functional connectivity
Functional magnetic resonance imaging
Graph convolutional network
High-order
High-order functional connectivity
Higher-order
Image edge detection
Peptide backbone-copper ring structure: A molecular insight into copper-induced amyloid toxicity
期刊论文
CHINESE PHYSICS B, 2022, 卷号: 31, 期号: 10
作者:
Wang, Jing
;
Li, Hua
;
Jiang, Xiankai
;
Wu, Bin
;
Guo, Jun
Adobe PDF(3745Kb)
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浏览/下载:372/0
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提交时间:2022/10/18
interactions between metal ion and protein
quantum chemistry calculation
protein aggregation
amyloid diseases
Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography
期刊论文
BIOMEDICAL OPTICS EXPRESS, 2022, 卷号: 13, 期号: 7, 页码: 3809-3822
作者:
Ren, Wuwei
;
Li, Linlin
;
Zhang, Jianru
;
Vaas, Markus
;
Klohs, Jan
Adobe PDF(16476Kb)
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收藏
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浏览/下载:269/0
|
提交时间:2022/07/15
Brain
Data acquisition
Deposits
Disease control
Diseases
Fluorescence imaging
Glycoproteins
Image reconstruction
Image segmentation
Mammals
Physiological models
Tomography
Alzheimer
Amyloid betas
Amyloid-beta peptides
Anatomical information
Disease burdens
Fluorescence molecular tomography
Fluorescence reflectance imaging
Mice models
Non-invasive monitoring
Patient models
Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway
期刊论文
MOLECULAR METABOLISM, 2022, 卷号: 59
作者:
Jiang, Bin
;
Wang, Dongdong
;
Hu, Yunfu
;
Li, Wenxuan
;
Liu, Fengjiang
Adobe PDF(5410Kb)
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收藏
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浏览/下载:660/0
|
提交时间:2022/03/29
Hepatic steatosis
NF-κB signaling pathway
Non-alcoholic fatty liver disease
Obesity
Serum amyloid A1
Toll-like receptor
Force Spectra of a Single CsgA Molecule and Amyloid Nanofibers Assembled from Chimeric Mfp5 and CBD Proteins: Implications for a Nanomaterial Testing Machine
期刊论文
ACS APPLIED NANO MATERIALS, 2022
作者:
Zhou, Kai
;
Liu, Yang
;
Li, Ke
;
Li, Yingfeng
;
Wei, Shicao
Adobe PDF(3612Kb)
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收藏
|
浏览/下载:226/0
|
提交时间:2022/03/07
CsgA monomer
beta-helix
amyloid
nanofiber
forced unfolding
single molecule
Functional amyloid-chitin hybrid ink coupled with flexible fabrication approaches for diverse macro and micro-structures
期刊论文
MATERIALS TODAY BIO, 2022, 卷号: 13
作者:
Wei, Shicao
;
Li, Yingfeng
;
Li, Ke
;
Kang, Anqi
;
Zhang, Siyu
Adobe PDF(2918Kb)
|
收藏
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浏览/下载:466/1
|
提交时间:2021/12/24
Cell culture
Cell engineering
Chitin
Enzyme immobilization
Genetic engineering
Glycoproteins
Self assembly
Tissue engineering
Bio-fabrication
Broad application
Chitin binding domains
Functional amyloid
Hybrid inks
Macrostructures
Micro-structures
Molecular complexes
Precise fabrications
Protein self-assemblies
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