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Combined treatment targeting Ca2+store mediated Ca2+release and store-operated calcium entry reduces secondary axonal degeneration and improves functional outcome after SCI
期刊论文
EXPERIMENTAL NEUROLOGY, 2025, 卷号: 386
作者:
Jones, Emma
;
Ames, Spencer O.
;
Brooks, Jesse
;
Morehouse, Johnny
;
Hill, Norah
Adobe PDF(5086Kb)
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浏览/下载:51/2
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提交时间:2025/03/03
Spinal cord injury
Store-operated calcium entry (SOCE)
Axoplasmic reticulum
Stromal interaction molecule proteins (STIM)
Orai
IP3R
Axonal degeneration
Peptide-Scaffolded Detergents for Membrane Protein Studies
期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2025, 卷号: 31, 期号: 16
作者:
Yang, Meifang
;
Dai, Yili
;
Zhou, Fang
;
Zhou, Xin
;
Qiu, Yanli
Adobe PDF(3689Kb)
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浏览/下载:31/2
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提交时间:2025/03/10
Peptide-scaffolded detergents
Membrane proteins
Micelle
Click reaction
Enzyme Surface Residues Direct Encapsulation into Metal–Organic Frameworks for Performance Regulation
期刊论文
ANGEWANDTE CHEMIE - INTERNATIONAL EDITION, 2025
作者:
Wu, Mengyao
;
Du, Yuexin
;
Xu, Hui
;
Zhang, Xiehaoran
;
Ma, Jialong
Adobe PDF(11670Kb)
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浏览/下载:21/2
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提交时间:2025/03/14
Crystalline materials - Enzyme activity - Enzyme immobilization - Metal-Organic Frameworks
Cytochrome c - Enzyme catalysis - Immobilisation - Metalorganic frameworks (MOFs) - Modified proteins - Performance - Structure-activity relationships - Surface residues - Surface-modification - Template synthesis
metal-organic frameworks
enzyme catalysis
template synthesis
immobilization
structure-activity relationships
Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy
期刊论文
ADVANCED SCIENCE, 2024
作者:
Yao Hu
;
Hao Yang
;
Mingwei Li
;
Zhicheng Zhong
;
Yongqi Zhou
Adobe PDF(6212Kb)
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浏览/下载:431/9
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提交时间:2024/09/11
conformational changes
deep learning
proteins
transition pathway
Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 29, 页码: 20045-20058
作者:
Liu, Hongyue
;
Yan, Pengfei
;
Zhang, Zhaoyu
;
Han, Hongbo
;
Zhou, Qingtong
Adobe PDF(7016Kb)
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浏览/下载:418/11
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提交时间:2024/08/09
Activation analysis
Chemical activation
Ligands
Proteins
'current
G protein
G protein coupled receptors
Limited proteolysis
Multiple domains
Receptor activation
Receptor signaling
Structural mass
Structural snapshots
Structural studies
Dynamic entity formed by protein and its hydration water
期刊论文
PHYSICAL REVIEW RESEARCH, 2024, 卷号: 6, 期号: 3
作者:
Ye, Yongfeng
;
Chen, Xiaoxia
;
Huang, Juan
;
Zheng, Lirong
;
Tang, Qingxue
Adobe PDF(1668Kb)
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浏览/下载:178/2
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提交时间:2024/10/11
Neutron scattering
Biomacromolecule
Different structure
Diverse proteins
Hydration water
Interaction strength
Isotope labeling
Protein system
Structure dynamics
Structure functions
Systematic evaluation
Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function
期刊论文
ADVANCED SCIENCE, 2024, 卷号: 11, 期号: 30
作者:
Zhang, Zichao
;
Chen, Jing
;
Ma, Rongze
;
Xu, Chongshen
;
Lu, Yunzhe
Adobe PDF(13234Kb)
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浏览/下载:145/2
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提交时间:2024/07/02
branching morphogenesis
centrosome
epithelial migration
RAB proteins
spindle organization
vertebrate-specific genes
vesicular trafficking
Generic protein-ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling
期刊论文
NATURE MACHINE INTELLIGENCE, 2024, 卷号: 6, 期号: 6, 页码: 688-700
作者:
Cao, Duanhua
;
Chen, Geng
;
Jiang, Jiaxin
;
Yu, Jie
;
Zhang, Runze
Adobe PDF(3326Kb)
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收藏
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浏览/下载:183/0
|
提交时间:2024/06/17
Graph neural networks
Lead compounds
Proteins
Data augmentation
Data-driven methods
Docking methods
Graph neural networks
Heterogeneous graph
Prior-knowledge
Protein-ligand interactions
Robust methods
Standing problems
Training data
GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases
期刊论文
INNOVATION, 2024, 卷号: 5, 期号: 2
作者:
Fang, Zheyan
;
Zhao, Gang
;
Zhao, Shuang
;
Yu, Xueting
;
Feng, Runyang
Adobe PDF(11456Kb)
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浏览/下载:395/2
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提交时间:2024/03/08
Amino acids
Chemical activation
Endothelial cells
Molecular biology
Transcription
Angiogenesis
Coactivators
Complementation
Endothelial-cells
Excision repair
Ischemic conditions
Neo-vascularization
Proteomics
Site directed mutagenesis
Target proteins
Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs
期刊论文
SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 6
作者:
Wang, James Jiqi
;
Jin, Sanshan
;
Zhang, Heng
;
Xu, Youwei
;
Hu, Wen
Adobe PDF(2350Kb)
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收藏
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浏览/下载:310/0
|
提交时间:2024/03/08
Blood pressure
Chemical activation
Proteins
Arterial hypertension
Blood pressure regulation
Coupled receptors
Cryo-electron microscopy
G protein
Inflammatory response
Ligand binding
Prostacyclin receptors
Receptor activation
Therapeutic targets
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