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Aberrant outputs of glutamatergic neurons in deep cerebellar nuclei mediate dystonic movements
期刊论文
SCIENCE ADVANCES, 2025, 卷号: 11, 期号: 19
作者:
Wu, Xue-Mei
;
Lu, Bin
;
He, Jun-Yan
;
Zhang, Yu-Xian
;
Wu, Zhi-Ying
Adobe PDF(7313Kb)
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浏览/下载:11/1
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提交时间:2025/05/26
Rats
Animal model
GABAergic
Kainic acid
Mice models
Mutant mice
Neuronal populations
Optogenetics
Selective ablations
Trans-membrane proteins
Transmembrane proteins
Combined treatment targeting Ca2+store mediated Ca2+release and store-operated calcium entry reduces secondary axonal degeneration and improves functional outcome after SCI
期刊论文
EXPERIMENTAL NEUROLOGY, 2025, 卷号: 386
作者:
Jones, Emma
;
Ames, Spencer O.
;
Brooks, Jesse
;
Morehouse, Johnny
;
Hill, Norah
Adobe PDF(5086Kb)
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浏览/下载:106/4
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提交时间:2025/03/03
Spinal cord injury
Store-operated calcium entry (SOCE)
Axoplasmic reticulum
Stromal interaction molecule proteins (STIM)
Orai
IP3R
Axonal degeneration
"Living Detergents": an in Situ Detergent Tailoring Strategy for Efficient Membrane Protein Stabilization and Analysis
期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2025
作者:
Dai, Yili
;
Yang, Meifang
;
Luo, Weiling
;
Qiu, Yanli
;
Zhou, Fang
Adobe PDF(1188Kb)
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浏览/下载:28/2
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提交时间:2025/05/06
bioorthogonal reaction
living detergent
membrane proteins
micelle
Introduction
The integration of artificial intelligence and protein science: the protein structure prediction and protein design revolution behind the 2024 Nobel Prize in Chemistry
期刊论文
CHINESE SCIENCE BULLETIN, 2025, 卷号: 70, 期号: 10, 页码: 1421-1427
作者:
Liu, Shenhui
;
Liu, Zhi-Jie
Adobe PDF(781Kb)
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浏览/下载:6/1
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提交时间:2025/05/30
Bioinformatics
Biomineralization
Elastin
Peptides
Vaccines
Alphafold2
Amino acid sequence
Artificial intelligence
Intelligence science
Nobel prize in chemistry
Nobel prizes
Protein design
Protein science
Protein structure prediction
Proteins structures
Peptide-Scaffolded Detergents for Membrane Protein Studies
期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2025, 卷号: 31, 期号: 16
作者:
Yang, Meifang
;
Dai, Yili
;
Zhou, Fang
;
Zhou, Xin
;
Qiu, Yanli
Adobe PDF(3689Kb)
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浏览/下载:85/3
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提交时间:2025/03/10
Peptide-scaffolded detergents
Membrane proteins
Micelle
Click reaction
Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models
期刊论文
NATURE BIOTECHNOLOGY, 2025
作者:
Feng, Xin
;
Jiang, Bo-Wen
;
Zhai, Si-Nan
;
Liu, Chu-Xiao
;
Wu, Hao
收藏
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浏览/下载:51/0
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提交时间:2025/04/11
Disease control
Neurodegenerative diseases
Neurons
Adeno-associated virus
Alzheimers disease
Disease phenotypes
Mice models
Neuroinflammation
Proinflammatory molecules
Protein kinase
RNA aptamer
Small-molecule inhibitors
Target proteins
Enzyme Surface Residues Direct Encapsulation into Metal–Organic Frameworks for Performance Regulation
期刊论文
ANGEWANDTE CHEMIE - INTERNATIONAL EDITION, 2025
作者:
Wu, Mengyao
;
Du, Yuexin
;
Xu, Hui
;
Zhang, Xiehaoran
;
Ma, Jialong
Adobe PDF(11670Kb)
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浏览/下载:80/4
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提交时间:2025/03/14
Crystalline materials - Enzyme activity - Enzyme immobilization - Metal-Organic Frameworks
Cytochrome c - Enzyme catalysis - Immobilisation - Metalorganic frameworks (MOFs) - Modified proteins - Performance - Structure-activity relationships - Surface residues - Surface-modification - Template synthesis
metal-organic frameworks
enzyme catalysis
template synthesis
immobilization
structure-activity relationships
Exploring Protein Conformational Changes Using a Large-Scale Biophysical Sampling Augmented Deep Learning Strategy
期刊论文
ADVANCED SCIENCE, 2024
作者:
Yao Hu
;
Hao Yang
;
Mingwei Li
;
Zhicheng Zhong
;
Yongqi Zhou
Adobe PDF(6212Kb)
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浏览/下载:499/10
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提交时间:2024/09/11
conformational changes
deep learning
proteins
transition pathway
Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 29, 页码: 20045-20058
作者:
Liu, Hongyue
;
Yan, Pengfei
;
Zhang, Zhaoyu
;
Han, Hongbo
;
Zhou, Qingtong
Adobe PDF(7016Kb)
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收藏
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浏览/下载:478/13
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提交时间:2024/08/09
Activation analysis
Chemical activation
Ligands
Proteins
'current
G protein
G protein coupled receptors
Limited proteolysis
Multiple domains
Receptor activation
Receptor signaling
Structural mass
Structural snapshots
Structural studies
Dynamic entity formed by protein and its hydration water
期刊论文
PHYSICAL REVIEW RESEARCH, 2024, 卷号: 6, 期号: 3
作者:
Ye, Yongfeng
;
Chen, Xiaoxia
;
Huang, Juan
;
Zheng, Lirong
;
Tang, Qingxue
Adobe PDF(1668Kb)
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收藏
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浏览/下载:209/2
|
提交时间:2024/10/11
Neutron scattering
Biomacromolecule
Different structure
Diverse proteins
Hydration water
Interaction strength
Isotope labeling
Protein system
Structure dynamics
Structure functions
Systematic evaluation
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