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Recent advances in targeted degradation in the RAS pathway 期刊论文
FUTURE MEDICINAL CHEMISTRY, 2025, 卷号: 17, 期号: 6
作者:  Ge, Zhiming;  Fan, Zisheng;  He, Wei;  Zhou, Guizhen;  Zhou, Yidi
Adobe PDF(2827Kb)  |  收藏  |  浏览/下载：25/2  |  提交时间：2025/03/25
CUL2-RING泛素连接酶识别羧基端降解子的机制 期刊论文
中国科学:化学, 2025
作者:  许超;  樊新元;  高新娇;  戚炜
Adobe PDF(1508Kb)  |  收藏  |  浏览/下载：66/1  |  提交时间：2025/02/28
Sorafenib and SIAIS361034, a novel PROTAC degrader of BCL-xL, display synergistic antitumor effects on hepatocellular carcinoma with minimal hepatotoxicity 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2024, 卷号: 230
作者:  Zhang, Xiaoyi;  Tao, Yachuan;  Xu, Zhongli;  Jiang, Biao;  Yang, Xiaobao
Adobe PDF(15900Kb)  |  收藏  |  浏览/下载：228/2  |  提交时间：2024/12/17
Emerging strategies to overcome PARP inhibitors' resistance in ovarian cancer 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2024, 卷号: 1879, 期号: 6
作者:  Bi, Ruomeng;  Chen, Li;  Huang, Mei;  Qiao, Zhi;  Li, Zhen
Adobe PDF(5547Kb)  |  收藏  |  浏览/下载：257/11  |  提交时间：2024/12/03
DiffPROTACs is a deep learning-based generator for proteolysis targeting chimeras 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 5
作者:  Li, Fenglei;  Hu, Qiaoyu;  Zhou, Yongqi;  Yang, Hao;  Bai, Fang
Adobe PDF(1631Kb)  |  收藏  |  浏览/下载：527/82  |  提交时间：2024/08/26
Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107
作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang
Adobe PDF(1940Kb)  |  收藏  |  浏览/下载：240/2  |  提交时间：2024/06/17
Development of the non-receptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023
作者:  Yanchun Zhang;  Xuexue Xiong;  Renhong Sun;  Xiaotong Zhu;  Chen Wang
Adobe PDF(2707Kb)  |  收藏  |  浏览/下载：323/4  |  提交时间：2023/09/25
The PROTAC selectively degrading Bcl-x(L) represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while bone 期刊论文
THERANOSTICS, 2022, 卷号: 12, 期号: 17
作者:  Zhang, Shaoqing;  Chen, Yue;  Xu, Zhongli;  Yang, Jun;  Sun, Renhong
Adobe PDF(2552Kb)  |  收藏  |  浏览/下载：708/191  |  提交时间：2022/12/07
Novel strategies to target EGFR proteins for degradation and their applications in non-small cell lung cancer 期刊论文
CHINESE JOURNAL OF NATURE, 2021, 卷号: 43, 期号: 6, 页码: 400-407
作者:  Xiaoling Song;  Xiaojuan Qu;  Siqi Qu;  Biao Jiang
Adobe PDF(1726Kb)  |  收藏  |  浏览/下载：627/9  |  提交时间：2021/12/30
Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 223, 页码: 113645
作者:  Liu HX(刘海霞);  Ding XY(丁欣雨);  Liu LY(刘林义)
Adobe PDF(2197Kb)  |  收藏  |  浏览/下载：531/5  |  提交时间：2021/09/18
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