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Bridging mechanical properties with atomic structures of polymorphic α-synuclein fibrils by single-molecule analysis and molecular dynamics simulations
期刊论文
AGGREGATE, 2025, 卷号: 6, 页码: e70023
作者:
Bi, Lulu
;
Li, Linge
;
Li, Xiang
;
Wu, Shaojuan
;
Zhang, Xia
Adobe PDF(4227Kb)
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收藏
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浏览/下载:121/7
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提交时间:2025/02/24
Crystal atomic structure
Molecular docking
Molecular dynamics
Neurodegenerative diseases
Dynamics simulation
Mechanical
Molecular simulations
Optical-
Parkinson's disease
Property
Single molecule
Single-molecule analysis
Α-syn fibril
α-synuclein
Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models
期刊论文
NATURE BIOTECHNOLOGY, 2025
作者:
Feng, Xin
;
Jiang, Bo-Wen
;
Zhai, Si-Nan
;
Liu, Chu-Xiao
;
Wu, Hao
收藏
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浏览/下载:26/0
|
提交时间:2025/04/11
Disease control
Neurodegenerative diseases
Neurons
Adeno-associated virus
Alzheimers disease
Disease phenotypes
Mice models
Neuroinflammation
Proinflammatory molecules
Protein kinase
RNA aptamer
Small-molecule inhibitors
Target proteins
Silk-Based Self-Unfolding Electrode Array for Minimally-invasive Large-Scale Deep Brain Activity Monitoring
会议论文
2025 IEEE 38TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS), Kaohsiung, Taiwan, 19-23 Jan. 2025
作者:
Jizhi Liang
;
Songtao Lai
;
Xiner Wang
;
Zhaohan Chen
;
Xiaoling Wei
收藏
|
浏览/下载:28/0
|
提交时间:2025/03/25
Brain
Cerebrospinal fluid
Electrophysiology
Neurodegenerative diseases
Neurons
Scaffolds
Scaffolds (biology)
Deep-brain neural interface
Electrode arrays
Large-scales
Microelectrodes arrays
Minimally invasive
Neural interfaces
Parkinsonian sheep model
Sheep model
Silk-enabled self-unfolding
Unfoldings
Amyloid-β Deposition Prediction with Large Language Model Driven and Task Oriented Learning of Brain Functional Networks
期刊论文
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2025, 卷号: PP, 期号: 99
作者:
Yuxiao Liu
;
Mianxin Liu
;
Yuanwang Zhang
;
Yihui Guan
;
Qihao Guo
Adobe PDF(2838Kb)
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收藏
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浏览/下载:151/5
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提交时间:2025/01/06
Functional neuroimaging
Neurodegenerative diseases
Neurophysiology
Positron emission tomography
Alzheimers disease
Brain networks
Convolutional networks
Emission tomography
Functional brain network
Functionals
Graph convolutional network
Language model
Large language model
Positron emission
Inhibitor Development for α‑Synuclein Fibril's Disordered Region to Alleviate Parkinson's Disease Pathology
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 41, 页码: 28282-28295
作者:
Zhang, Shenqing
;
Xiang, Huaijiang
;
Tao, Youqi
;
Li, Juan
;
Zeng, Shuyi
Adobe PDF(12245Kb)
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浏览/下载:361/12
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提交时间:2024/09/27
Neurodegenerative diseases
Nuclear magnetic resonance spectroscopy
Targeted drug delivery
Amyloid fibril
Disordered regions
EM techniques
High throughput screening
Intrinsically disordered regions
Membrane receptors
Pathological effects
Solid state NMR
Structure-activity relationships
α-synuclein
Identification of novel tau positron emission tomography tracers for chronic traumatic encephalopathy by comprehensive in silico screening and molecular dynamics simulation
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2024
作者:
Qi, Bote
;
Guan, Lulu
;
Tan, Jingwang
;
Li, Gengchen
Adobe PDF(3086Kb)
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收藏
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浏览/下载:90/1
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提交时间:2024/12/27
Binding energy
Computerized tomography
Germanium compounds
Neurodegenerative diseases
Neurophysiology
Photons
Positron emission tomography
Positrons
Binding affinities
Dynamics simulation
Emission tomography
Hydrogen bonding interactions
Hydrophobics
In-silico screening
Mild traumatic brain injuries
Neurodegenerative
Positron emission
Protofibrils
Mild Traumatic Brain Injury and Career Stage Associate with Visible Perivascular Spaces in Special Operations Forces Soldiers
期刊论文
ANNALS OF BIOMEDICAL ENGINEERING, 2024, 卷号: 52, 期号: 10, 页码: 2812-2817
作者:
Powell, Jacob R.
;
Zong, Xiaopeng
;
Weinstein, Joshua M.
;
DeLellis, Stephen M.
;
Kane, Shawn F.
Adobe PDF(864Kb)
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收藏
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浏览/下载:227/1
|
提交时间:2024/03/08
Magnetic resonance imaging
Neurodegenerative diseases
Neuroimaging
Blast
Blast exposures
Career stages
Concussion
Disease risks
Glymphatic
Mild traumatic brain injuries
Military
Space volume
Special operation forces
Asynchronous Functional Brain Network Construction with Spatiotemporal Transformer for MCI Classification
期刊论文
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2024, 卷号: PP, 期号: 99
作者:
Jianjia Zhang
;
Xiaotong Wu
;
Xiang Tang
;
Luping Zhou
;
Lei Wang
Adobe PDF(2613Kb)
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收藏
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浏览/下载:176/1
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提交时间:2024/10/28
Brain mapping
Computer aided diagnosis
Computer aided network analysis
Neurodegenerative diseases
Alzheimers disease
Brain networks
Computer-aided
Functional brain network
Functional connectivity
Functionals
Region-of-interest
Regions of interest
Resting-state functional magnetic resonance imaging
Transformer
Exploring Multiconnectivity and Subdivision Functions of Brain Network via Heterogeneous Graph Network for Cognitive Disorder Identification
期刊论文
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2024, 卷号: PP, 期号: 99
作者:
Dongdong Chen
;
Mengjun Liu
;
Zhenrong Shen
;
Linlin Yao
;
Xiangyu Zhao
Adobe PDF(2862Kb)
|
收藏
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浏览/下载:174/2
|
提交时间:2024/10/28
Brain mapping
Data flow graphs
Network coding
Neurodegenerative diseases
Brain connectivity
Brain functions
Brain network analyze
Brain networks
Graph networks
Graph neural network
Graph neural networks
Heterogeneous graph
Human intelligence
Self-attention
Multimodal transformer network for incomplete image generation and diagnosis of Alzheimer's disease
期刊论文
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, 2023, 卷号: 110
作者:
Gao, Xingyu
;
Shi, Feng
;
Shen, Dinggang
;
Liu, Manhua
Adobe PDF(7954Kb)
|
收藏
|
浏览/下载:246/0
|
提交时间:2023/11/24
Brain mapping
Deep learning
Diagnosis
Magnetic resonance imaging
Neurodegenerative diseases
Positron emission tomography
Alzheimers disease
Brain images
Disease diagnosis
Image generations
Missing data
Multi-modal
Multilevels
Multimodal brain image
Multimodal images
Transformer
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