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A DXd/TLR7-Agonist Dual-Conjugate Anti-HER2 ADC Exerts Robust Antitumor Activity Through Tumor Cell Killing and Immune Activation 期刊论文
MOLECULAR CANCER THERAPEUTICS, 2024, 卷号: 23, 期号: 11
作者:  Yue, Hangtian;  Xu, Hui;  Ma, Lanping;  Li, Xiyuan;  Yang, Biyu
Adobe PDF(4235Kb)  |  收藏  |  浏览/下载：40/2  |  提交时间：2024/09/21
Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway 期刊论文
RESEARCH, 2023, 卷号: 6
作者:  Jiang, Yu;  Li, Xiyuan;  Qian, Fenghui;  Sun, Bingbing;  Wang, Xiyuan
Adobe PDF(1153Kb)  |  收藏  |  浏览/下载：306/1  |  提交时间：2023/04/21
Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation 期刊论文
CANCER SCIENCE, 2022, 卷号: 113, 期号: 9, 页码: 2974-2985
作者:  Du, Mengyan;  Yu, Ting;  Zhan, Qinjinge;  Li, Han;  Zou, Yiping
Adobe PDF(10387Kb)  |  收藏  |  浏览/下载：164/1  |  提交时间：2022/11/08
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220
作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng
Adobe PDF(1741Kb)  |  收藏  |  浏览/下载：201/0  |  提交时间：2021/07/23
SAF-189s, a potent new-generation ROS1 inhibitor, is active against crizotinib-resistant ROS1 mutant-driven tumors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021
作者:  Xia, Zong-jun;  Ji, Yin-chun;  Sun, De-qiao;  Peng, Xia;  Gao, Ying-lei
Adobe PDF(2184Kb)  |  收藏  |  浏览/下载：240/4  |  提交时间：2020/11/02
Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3 期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 12, 页码: 1885-1893
作者:  Fang, Tian;  Liu, Dan-dan;  Ning, He-ming;  Liu, Dan;  Sun, Jing-ya
Adobe PDF(3477Kb)  |  收藏  |  浏览/下载：376/3  |  提交时间：2019/01/18
Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 76-86
作者:  Geng, Kaijun;  Liu, Hongchun;  Song, Zilan;  Zhang, Chi;  Zhang, Minmin
Adobe PDF(1841Kb)  |  收藏  |  浏览/下载：340/1  |  提交时间：2018/07/02
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang
Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：450/1  |  提交时间：2018/07/02
Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 144, 页码: 386-397
作者:  Geng, Kaijun;  Xia, Zongjun;  Ji, Yinchun;  Zhang, Ruisi (Ruthy);  Sun, Deqiao
Adobe PDF(1645Kb)  |  收藏  |  浏览/下载：378/1  |  提交时间：2018/04/11
Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis 期刊论文
CANCER LETTERS, 2018, 卷号: 431, 页码: 150-160
作者:  Zhang, Xiong;  Zheng, Xingling;  Yang, Hong;  Yan, Juan;  Fu, Xuhong
Adobe PDF(3937Kb)  |  收藏  |  浏览/下载：384/1  |  提交时间：2018/08/09