A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection

doi:10.1038/s41467-019-12323-1

	A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection
	Cui, Chunlai 1,2; Wang, Yan 1,2; Liu, Jingnan3 ; Zhao, Jing 1; Sun, Peilu 1; Wang, Sibao 1
	2019-09-20
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	10
发表状态	已发表
DOI	10.1038/s41467-019-12323-1
摘要	Insecticidal fungi represent a promising alternative to chemical pesticides for disease vector control. Here, we show that the pathogenic fungus Beauveria bassiana exports a microRNA-like RNA (bba-milR1) that hijacks the host RNA-interference machinery in mosquito cells by binding to Argonaute 1 (AGO1). bba-milR1 is highly expressed during fungal penetration of the mosquito integument, and suppresses host immunity by silencing expression of the mosquito Toll receptor ligand Spatzle 4 (Spz4). Later, upon entering the hemocoel, bba-milR1 expression is decreased, which avoids induction of the host proteinase CLIPB9 that activates the melanization response. Thus, our results indicate that the pathogen deploys a cross-kingdom small-RNA effector that attenuates host immunity and facilitates infection.
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收录类别	SCI ; SCIE
语种	英语
资助项目	One Hundred Talents Program of the Chinese Academy of Sciences[2013OHTP01]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000486995200008
出版者	NATURE PUBLISHING GROUP
WOS关键词	ENTOMOPATHOGENIC FUNGI ; INSECTICIDE RESISTANCE ; CONTROL AGENTS ; MALARIA ; HEMOCYTES ; TARGETS
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/80225
专题	生命科学与技术学院_PI研究组_刘冀珑组
通讯作者	Wang, Sibao
作者单位	1.Chinese Acad Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Ctr Excellence Mol Plant Sci,Shanghai Inst Biol S, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Cui, Chunlai,Wang, Yan,Liu, Jingnan,et al. A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection[J]. NATURE COMMUNICATIONS,2019,10.
APA	Cui, Chunlai,Wang, Yan,Liu, Jingnan,Zhao, Jing,Sun, Peilu,&Wang, Sibao.(2019).A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection.NATURE COMMUNICATIONS,10.
MLA	Cui, Chunlai,et al."A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection".NATURE COMMUNICATIONS 10(2019).