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Discovery of toxoflavin, a potent IRE1a inhibitor acting through structure-dependent oxidative inhibition (vol 44, 234, 2023) 其他
ACTA PHARMACOLOGICA SINICA, 2023-08-01
作者:  Jiang, Kai-long;  Liu, Chang-mei;  Nie, Li-tong;  Jiang, Hai-ni;  Xu, Lei
Adobe PDF(252Kb)  |  收藏  |  浏览/下载：110/25  |  提交时间：2023/10/23
Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors 期刊论文
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8
作者:  Xu, Lei;  Xuyan, Xuyang;  Minmi, Minmin;  Wang, Zhiji;  Shee, Chao
Adobe PDF(1267Kb)  |  收藏  |  浏览/下载：129/0  |  提交时间：2023/07/24
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo
Adobe PDF(2766Kb)  |  收藏  |  浏览/下载：514/208  |  提交时间：2021/12/27
Discovery of toxoflavin, a potent IRE1 alpha inhibitor acting through structure-dependent oxidative inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Jiang, Kai-long;  Liu, Chang-mei;  Nie, Li-tong;  Jiang, Hai-ni;  Xu, Lei
Adobe PDF(2249Kb)  |  收藏  |  浏览/下载：129/0  |  提交时间：2022/08/15
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Jiang, Kai-long;  Tong, Le-xian;  Wang, Tao;  Wang, Han-lin;  Hu, Xiao-bei
Adobe PDF(3825Kb)  |  收藏  |  浏览/下载：206/0  |  提交时间：2021/04/19
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong
Adobe PDF(5151Kb)  |  收藏  |  浏览/下载：150/0  |  提交时间：2021/11/19
Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021
作者:  Zhang, Xiao-tuan;  Hu, Xiao-bei;  Wang, Han-lin;  Kan, Wei-juan;  Xu, Lei
Adobe PDF(2353Kb)  |  收藏  |  浏览/下载：152/0  |  提交时间：2020/09/18
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021
作者:  Sun,shuimei;  Xie,zhifu;  Zhang,yangming;  Zhang,xinwen;  Zhou,chedong
Adobe PDF(1601Kb)  |  收藏  |  浏览/下载：169/0  |  提交时间：2020/08/05
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218
作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei
Adobe PDF(1954Kb)  |  收藏  |  浏览/下载：139/0  |  提交时间：2021/06/04
Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction 期刊论文
ARCHIV DER PHARMAZIE, 2020
作者:  Xiao, Donghuai;  Wang, Yu-jie;  Wang, Han-lin;  Zhou, Yu-bo;  Li, Jia
Adobe PDF(1428Kb)  |  收藏  |  浏览/下载：137/0  |  提交时间：2020/05/14